Study of Crystalline Drugs by Means of Polarizing Microscope. I. Identification of Polymorphic or Solvated Forms in Thiamine Hydrochloride, Bromvalerylurea and Ampicillin

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概要

• 論文の詳細を見る

• The microscopic study of crystalline substances using a polarizing microscope and the immersion media was shown to have an advantage of simple and rapid identification of drugs, especially in polymorphs or solvates. Examples of the application of this technique were given for four crystal forms of thiamine hydrochloride, two forms of each bromvalerylurea and ampicillin. The accuracy and reproducibility of the measured refractive indices are discussed with its relation to crystal habit.

• 公益社団法人日本薬学会の論文
• 1977-09-25

著者

• 渡辺 厚

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• 渡辺 厚

  Kenbikogaku-kenkyusho Ltd.

• 田中 洋子

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 田中 由美子

  Faculty of Pharmaceutical Sciences, Kobegakuin University

• 田中 洋子

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 渡辺 厚

  Faculty Of Pharmaceutical Sciences Kobegakuin University

• 田中 由美子

  Faculty Of Pharmaceutical Sciences Kobegakuin University

関連論文

• Crystal Habits and Dissolution Behavior of Aspirin
• Alkylnaphthalenes. I. : Absorption, Tissue Distribution and Excretion of 2,6-Diisopropylnaphthalene in Rats
• Study of Crystalline Drugs by Means of a Polarizing Microscope. VIII. : A Simple and Rapid Method to Measure the Thickness of a Crystalline Drug and Its Application to the Quality Testing of Poorly Soluble Drugs
• Study of Crystalline Drugs by Means of Polarizing Microscope. I. Identification of Polymorphic or Solvated Forms in Thiamine Hydrochloride, Bromvalerylurea and Ampicillin
• Polymorphism of Thiamine Hydrochloride. II. Crystal Structure of Thiamine Hydrochloride Hemihydrate and Its Stability
• Identification of the Polymorphs of Sulfamethoxydiazine by Optical and Morphological Methods

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