有害性金属に関する研究(第4報)塩化第二錫のラット消化管吸収とその吸収におよぼす各種食品成分の影響

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In order to examine the characteristics of intestinal absorption of stannic chloride, an in vitro experiment was carried out by circulating the reagent through segments of everted rat small intestine. The disappearance of tin from the mucosal solutions of rat duodenum, jejunum, and ileum followed apparent first-order kinetics. Tin absorption was approximately proportional to the concentration of tin in the mucosal solution and no difference was observed in the absorptions by rat duodenum, jejunum, and ileum. These results suggested that the absorption of tin from the rat small intestine occurs by passive diffusion. The effect of various food components such as organic acids, amino acids, and proteins on tin absorption from the rat intenstine and on its uptake by the intestine was also studied by the use of the small intestine in vitro and in vivo. Organic acids such as citric acid, tartaric acid, malic acid, and ascorbic acid significantly enhanced the tin absorption in vitro and in vivo. Tin uptake greatly decreased in the presence of these acids. Amino acids such as L-histidine, L-proline, and L-glutamic acid, and proteins such as ovalbumin and gelatin had little effect on tin absorption in vitro and in vivo. In addition, it was suggested that the effect of citric acid on the intestinal absorption of tin was due to a modification of intestinal permeability and the enhanced permeation of tin across the intestine in the form of tin-citric acid complex.
公益社団法人日本薬学会の論文
1978-04-25

有害性金属に関する研究(第4報)塩化第二錫のラット消化管吸収とその吸収におよぼす各種食品成分の影響

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