L-ヒスチジン及びL-ロイシンの小腸吸収に対する必須金属の影響

概要

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The effects of essential metals, such as Zn, Cu, Mn, Ni, and Co, on the small intestinal absorption of L-histidine and L-leucine in rats were studied. The absorption of L-histidine (0.5 mM) from the small intestine in situ was significantly depressed by the presence of copper and nickel (0.5 mM) in the lumen, and the absorption of L-leucine (0.5 mM) was significantly depressed by the presence of copper. The absorption of L-histidine and L-leucine from the small intestine after pretreatment with copper (0.5 mM) for 1h was more significantly depressed than that of control. However, the pretreatment of the small intestine with nickel did not depress the absorption of L-histidine. The depressed absorption of L-histidine from the small intestine in situ in the presence of copper was significantly restored by the increase in the concentration of L-histidine. These results suggested that the formation of a stable copper-and nickel-L-histidine complex may decrease the amount of free L-histidine available to be absorbed from the intestine, resulting in a decrease in the intestinal absorption of L-histidine. In addition, an in vitro intestinal experiment suggested that copper taken up by the intestinal tissue inhibits the active transport of L-histidine and L-leucine across the small intestine.
社団法人日本薬学会の論文
1988-12-31