有害性金属に関する研究(第1報)塩化カドミウムのin Vitroでのラット小腸透過ならびにその透過におよぼすキレート剤の影響

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The transport of cadmium chloride across the rat intestine in vitro was studied by the perfusion method using the segments of everted rat small intestine. The disappearance of cadmium from the mucosal solutions of rat duodenum, jejunum, and ileum followed apparent first-order kinetics. In this case, cadmium transported from the mucosal to the serosal side of each region of the intestine was small in amount and a large portion of the metal in the mucosal solution was taken up by the intestinal tissue. Cadmium transport was approximately proportional to the metal concentration in the mucosal solution and no difference was observed in the metal transport among rat duodenum, jejunum, and ileum. It was suggested from these results that cadmium transport across the rat small intestine would occur by passive diffusion. The effect of various chelating agents on cadmium transport across the rat small intestine in vitro and its uptake by the intestine were also studied. Cadmium transport was greatly enhanced in the presence of trans-1,2-cyclo-hexanediamine-N, N, N', N'-tetraacetic acid (CyDTA), ethylenediaminetetraacetic acid (EDTA), and nitrilotriacetic acid (NTA) and, to a lesser degree, in the presence of citric acid and succinic acid. Cadmium uptake decreased to a greater extent in the presence of CyDTA, EDTA, and NTA. In addition, it was suggested that the effect of EDTA on the intestinal transfer of cadmium was not due to a modification of intestinal permeability characteristics but possibly due to the enhanced transport of cadmium across the intestine in the form of cadmium-EDTA complex.
1974-06-25

有害性金属に関する研究(第1報)塩化カドミウムのin Vitroでのラット小腸透過ならびにその透過におよぼすキレート剤の影響

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