Effects of Simultaneous Administration of Drugs on Absorption and Excretion. I. Effect of Phenylbutazone on Absorption and Excretion of Sodium Cyclamate in Rabbits
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概要
- 論文の詳細を見る
The urinary excretion of sodium cyclamate (CHS-Na) in rabbits was accelerated by the simultaneous administration of phenylbutazone, and the excretion rate constant of CHS-Na increased in accordance with an increase in the dose of phenylbutazone. In the experiment of intestinal recirculating perfusion, phenylbutazone did not accelerate the intestinal absorption of CHS-Na in rabbits. And the competitive inhibitory effect of phenylbutazone on the binding between CHS-Na and bovine serum albumin was found in the equilibrium dialysis experiment. Accordingly, these results demonstrate that the acceleration of the urinary excretion of CHS-Na in the rabbits following simultaneous administration of phenylbutazone is attributed to the competitive inhibitory effect of phenylbutazone in the binding between CHS-Na and rabbit serum albumin.
- 公益社団法人日本薬学会の論文
- 1972-05-25
著者
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児島 昭次
Dept. Of Hygienic Chem. Fac. Pharm. Sci. Kumamoto Univ.
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児島 昭次
Faculty Of Pharmaceutical Sciences Kumamoto University
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今村 順茂
Faculty of Pharmaceutical Sciences, Kumamoto University
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今村 順茂
Faculty Of Pharmaceutical Sciences Kumamoto University
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一番ヶ瀬 尚
Faculty of Pharmaceutical Sciences, Kumamoto University
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木下 昭生
Faculty Of Pharmaceutical Science Kumamoto University
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一番ヶ瀬 尚
Faculty Of Pharmaceutical Sciences Kumamoto University
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