Effects of Simultaneous Administration of Drugs on Absorption and Excretion. IV. Effect of Salicylic Acid on Antibacterial Activity and Distribution of Sulfadimethoxine in Rabbits
スポンサーリンク
概要
- 論文の詳細を見る
1. Plasma levels of sulfadimethoxine determined by bioassay, namely antibacterial activities, were markedly low in comparison with that of sulfadimethoxine determined by chemical assay in rabbits. 2. The antibacterial activities of sulfadimethoxine in rabbits following intravenous administration of sulfadimethoxine were significantly increased by the concomitant administration of salicylic acid. 3. On the other hand, plasma levels of sulfadimethoxine determined by chemical assay in rabbits following intravenous administration of sulfadimethoxine were decreased by the concomitant administration of salicylic acid. 4. These results suggest that the distribution of sulfadimethoxine from blood to tissues is enhanced by salicylic acid.
- 公益社団法人日本薬学会の論文
- 1974-10-25
著者
-
今村 順茂
Faculty of Pharmaceutical Sciences, Kumamoto University
-
今村 順茂
Faculty Of Pharmaceutical Sciences Kumamoto University
-
一番ケ瀬 尚
Faculty of Pharmaceutical Sciences, Kumamoto University
-
一番ケ瀬 尚
熊本大薬
-
一番ケ瀬 尚
Faculty Of Pharmaceutical Sciences Kumamoto University
-
重盛 啓子
熊本大学薬学部
-
重盛 啓子
Faculty of Pharmaceutical Sciences, Kumamoto University
関連論文
- Characterization of Binding Sites for Sulfadimethoxine and Its Major Metaboite, N^4-Acetylsulfadimethoxine, on Human and Rabbit Serum Albumin
- β-シクロデキストリン複合体化によるアセトヘキサミドのバイオアベイラビリティの向上
- クマリン誘導体の合成研究(第25報) : 4-Methyl-6-acetyl-7-hydroxycoumarinおよび4-Methyl-7-hydroxy-8-acetylcoumarinのニトロ誘導体の合成
- Species Difference in the in Vitro Metabolic Reduction of Acetohexamide
- Pyridinolcarbamateに関する生物薬剤学的研究(第4報)家兎におけるトルブタマイドとクロルブロバマイドの血糖降下作用におよぼすPyridinolcarbamate連続投与の影響
- Inclusion Complex of Acetohexamide with β-Cyclodextrin and Its Hypoglycemic Activity in Rabbit
- Pyridinolcarbamateに関する生物薬剤学的研究(第3報)家兎におけるフェノールスルフォンフタレイン, p-アミノ馬尿酸, マンニトールおよびイヌリンの腎排泄に及ぼすPyridinolcarbamate連続投与の影響
- Pyridinolcarbamateに関する生物薬剤学的研究(第2報)Pyridinolcarbamateの家兎尿中代謝産物の単離, 同定
- Pyridinolcarbamateに関する生物薬剤学的研究(第1報)家兎におけるサルファ剤の腎排泄に及ぼすPyridinolcarbamate連続投与の影響
- Studies on Synthetic Sweetening Agents. XVII. Metabolism of Sodium Cyclamate. (6). Influences of Neomycin and Sulfaguanidine on Metabolism of Sodium Cyclamate
- Studies on Synthetic Sweetening Agents. XVI. Metabolism of Sodium Cyclamate. (5). The Metabolism of Sodium Cyclamate in Rabbits and Rats after Prolonged Adiministration of Sodium Cyclamate
- Contribution of N^4-Acetylsulfadimethoxine to the Interaction of Sulfadimethoxine with Ketoprofen in Rabbits(Pharmaceutical)
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XVI. Effect of Probenecid on Plasma Protein Binding of Sulfadimethoxine in Fast and Slow Acetylator Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XV. Effect of Probenecid on Plasma Protein Binding of Sulfadimethoxine in Rabbits : The Role of N^4-Acetylsulfadimethoxine, the Major Metabolite of Sulfadimethoxine
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XIII. Effect of Salicylic Acid on the Absorption, Distribution and Elimination of Carbutamide in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XII. Effect of Salicylic Acid on Hypoglycemic Activity and Blood Concentration of Carbutamide in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. X. Plasma Protein Binding of Carbutamide in Rabbits
- Mechanism of Inhibition of Carbonyl Reductase from Rabbit Kidney by Phenylbutazone
- Influence of Aging on Acetohexamide Reductase Activities in Liver Microsomes and Cytosol of Male Rats
- Kinetics of Befunolol Reductase from Rabbit Liver
- Purification and Characterization of Befunolol Reductase from Rabbit Liver
- Further Studies on Reductive Metabolism of Acetohexamide in Heart
- Effect of pH Small Inorganic Ions on Binding of Sulfadimethoxine and Sulfaphenazole to Human Serum Albumin Measured by Circular Dichroism
- Study on the Binding of Dicumarol to α_1-Acid Glycoprotein Using Circular Dichroism Spectroscopy
- クマリン誘導体の合成研究(第21報) : 3-Coumarinacetamideおよび3,4-Dihydro-2-oxo-2H-benzopyran-3-carboxamide誘導体の合成
- Studies on Metabolic Reduction of Befunolol in Rabbit Liver and Kidney
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XVIII. Differential Effects of Oral and Rectal Administration of Chloral Hydrate on the Gastrointestinal Absorption of Sulfisoxazole in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XIX. Binding of Acetohexamide and Its Major Metabolite, (-)-Hydroxyhexamide, to Human Serum Albumin
- 吸収排泄におよぼす医薬品の併用効果(第7報) : In Vitroにおけるサルファ剤の抗菌活性におよぼすタンパク結合の影響
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. VI. Effect of Protein Binding on Membrane Permeability of Sulfonamides
- Effects of Simultaneous Administration of Drugs on Absorption and Excretion. I. Effect of Phenylbutazone on Absorption and Excretion of Sodium Cyclamate in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XVII. In Vivo Protein Binding Interaction between Sulfamethoxazole and Chloral Hydrate in Rabbits
- 吸収排泄におよぼす医薬品の併用効果(第14報)家兎におけるSulfisomidineの消化管吸収におよぼすAtropineの影響
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XI. Effect of Diphenhydramine on Sulfisomidine Absorption in Rabbits
- 吸収排泄におよぼす医薬品の併用効果(第9報)家兎におけるサルファ剤の血中濃度に及ぼすサリチル酸の影響
- 薬効検定と薬物評価(医薬品長期対策委員会の答申について)
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. VIII. Effect of Plasma-Protein Binding Displacement on the Intestinal Absorption of Sulfonamides in Rabbits
- Effects of Simultaneous Administration of Drugs on Absorption and Excretion. V. Effect of Phenylbutazone on Antibacterial Activity and Distribution of Sulfadimethoxine in Rabbits
- Effects of Simultaneous Administration of Drugs on Absorption and Excretion. IV. Effect of Salicylic Acid on Antibacterial Activity and Distribution of Sulfadimethoxine in Rabbits
- Effects of Simultaneous Administration of Drugs on Absorption and Excretion. II. Effects of Non-steroidal Anti-inflammatory Drugs on Absorption and Excretion of Sulfadimethoxine in Rabbits
- METABOLIC REDUCTION OF ACETOHEXAMIDE BY RABBIT TISSUES
- Studies on Synthetic Sweetening Agents. XIV. Metabolism of Sodium Cyclamate. (3). On Metabolites of Sodium Cyclamate in Human
- Studies on Synthesis of Coumarin Derivatives. XXIII. Synthesis and Antibacterial Activity of Derivatives of 3-Substituted-7-amino-4-hydroxy-coumarin
- Studies on Synthesis of Coumarin Derivatives. XX. Synthesis and Antibacterial Activity of Derivatives of N-Substituted 3-Coumarincarboxamide
- Studies on Synthetic Sweetening Agents. XII. The Binding of Sodium Cyclamate with Bovine Serum Albumin
- 人工甘味料に関する研究(第11報) : ズルチンの比色定量 その2
- クマリン誘導体の合成研究(第17報) : 4-Hydroxy-3-sulfanilamidocoumarin誘導体の合成
- サルファ剤の1新微生物定量法