Studies on Metabolic Reduction of Befunolol in Rabbit Liver and Kidney
スポンサーリンク
概要
- 論文の詳細を見る
The metabolic reduction of befunolol was studied using rabbit liver and kidney preparations. Befunolol was mainly reduced in the cytosols of liver and kidney and its reduction was mediated by an NADPH (nicotinamide adenine dinucleotide phosphate, reduced form)-dependent enzyme with a pH optimum in the range of 6.0 to 7.0. Rather similar K_m (Michaelis constant) and V_<max> (maximal velocity) values observed for befunolol reduction in the cytosols of liver and kidney, and plant flavonoids (quercitrin, quercetin) and sulfhydryl reagents markedly inhibited the befunolol feducition. These findings indicate that the metabolic reduction of befunolol in the liver and kidney is catalyzed by the same carbonyl reductase. Furthemore, it was suggested that the befunolol-reducing enzyme might be a 3α-hydroxysteroid dehydrogenase on the basis of the inhibitory effects of various nonsteroidal anti-inflammatory drugs.
- 公益社団法人日本薬学会の論文
- 1988-02-25
著者
-
小田切 優樹
Faculty of Pharmaceutical Science, Kumamoto University
-
今村 順茂
Faculty of Pharmaceutical Sciences, Kumamoto University
-
今村 順茂
熊本大学薬学部
-
今村 順茂
熊本大学大学院医学薬学研究部
-
今村 順茂
Faculty Of Pharmaceutical Sciences Kumamoto University
-
今井 輝子
Faculty of Pharmaceutical Sciences, Kumamoto University
-
野崎 誉士秀
熊本大学薬学部
-
野崎 誉士秀
Faculty of Pharmaceutical Sciences, Kumamoto University
関連論文
- Evaluation of Quinaldine Red as a Fluorescent Probe for Studies of Drug-α_1-Acid Glycoprotein Interaction
- Characterization of Drug Binding Sites on α_1-Acid Glycoprotein
- Characterization of Binding Sites for Sulfadimethoxine and Its Major Metaboite, N^4-Acetylsulfadimethoxine, on Human and Rabbit Serum Albumin
- Analysis of Interfacial Transfer and Absorption Behavior of Drugs Following Dissolution from β-Cyclodextrin Complexes
- ALLEVIATION OF PROCHLORPERAZINE-INDUCED PRIMARY IRRITATION OF SKIN BY CYCLODEXTRIN COMPLEXATION
- 熊本県沿岸域の巻貝における環境ホルモンの影響評価(第5報) : 教材に適したイポニシの採取時期と場所(2)
- 熊本県沿岸域の巻貝における環境ホルモンの影響評価(第4報) : 教材に適したイボニシの採取時期と場所
- 熊本県沿岸域の巻貝における環境ホルモンの影響評価(第3報) : 環境教育の教材として用いるイボニシの採取時間について
- 熊本県沿岸域の巻貝における環境ホルモンの影響評価(第2報) : 環境教育教材としての情報収集
- A-2 熊本県沿岸域の巻貝を用いた環境教育の試み(研究発表,平成17年度日本理科教育学会九州支部総会)
- カルボニル還元酵素の有用性 (特集 生体触媒反応とプロセス)
- Species Difference in the in Vitro Metabolic Reduction of Acetohexamide
- Inclusion Mode of Flurbiprofen with β-Cyclodextrin and Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin, and Improvements of Some Pharmaceutical Properties of Flurbiprofen by Complexation
- Pyridinolcarbamateに関する生物薬剤学的研究(第4報)家兎におけるトルブタマイドとクロルブロバマイドの血糖降下作用におよぼすPyridinolcarbamate連続投与の影響
- Inclusion Complex of Acetohexamide with β-Cyclodextrin and Its Hypoglycemic Activity in Rabbit
- Pyridinolcarbamateに関する生物薬剤学的研究(第3報)家兎におけるフェノールスルフォンフタレイン, p-アミノ馬尿酸, マンニトールおよびイヌリンの腎排泄に及ぼすPyridinolcarbamate連続投与の影響
- ウサギ肝臓カルボニル還元酵素のアセトヘキサミドおよび4-アセチルピリジン誘導体に対する諸性質(発表論文抄録(1994))
- Pyridinolcarbamateに関する生物薬剤学的研究(第2報)Pyridinolcarbamateの家兎尿中代謝産物の単離, 同定
- Pyridinolcarbamateに関する生物薬剤学的研究(第1報)家兎におけるサルファ剤の腎排泄に及ぼすPyridinolcarbamate連続投与の影響
- Characterization of High Affinity Binding Sites of Non-steroidal Anti-inflammatory Drugs with Respect to Site-Specific Probes on Human Serum Albumin
- ペルオキシソームに局在する4量体カルボニル還元酵素の構造と機能
- 迅速及び緩徐アセチル化型ウサギにおけるスルファジメトキシンの血漿中濃度と組織分布に及ぼすプロペネシドの影響
- Contribution of N^4-Acetylsulfadimethoxine to the Interaction of Sulfadimethoxine with Ketoprofen in Rabbits(Pharmaceutical)
- 家兎におけるin Vivoとin Vitroでのスルフォンアミド類の血清蛋白結合
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XVI. Effect of Probenecid on Plasma Protein Binding of Sulfadimethoxine in Fast and Slow Acetylator Rabbits
- 正常及びアロキサン糖尿病家兎におけるカルブタミドの血清蛋白結合
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XIII. Effect of Salicylic Acid on the Absorption, Distribution and Elimination of Carbutamide in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XII. Effect of Salicylic Acid on Hypoglycemic Activity and Blood Concentration of Carbutamide in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. X. Plasma Protein Binding of Carbutamide in Rabbits
- Characterization of Region Ic in Site I on Human Serum Albumin. Microenvironmental Analysis Using Fluorescence Spectroscopy
- 家兎におけるスルファジメトキシンとスルフイソキサゾールの体内動態に及ぼす炭酸水素ナトリウムの異なる効果
- 実験動物の肝ミクロソームにおけるアセトヘキサミド還元酵素と20β-ヒドロキシステロイド脱水素酵素活性の系統差,性差及び種差
- ケトン基を有する薬物の還元的代謝を制御する生理的, 遺伝的及び病的因子
- ウサギ腎由来のカルボニル還元酵素により触媒されるアセトヘキサミドの還元反応におけるケトン性薬物の抑制効果に関する研究
- ブタ心臓カルボニルレダクターゼの精製と諸性質
- ラット肝臓20β-Hydroxysteroid Dehydrogenaseによる抗糖尿病薬アセトヘキサミド還元的代謝
- ウサギ肝臓カルボニルレダクターゼの活性アミノ酸残基について(2)
- Mechanism of Inhibition of Carbonyl Reductase from Rabbit Kidney by Phenylbutazone
- Influence of Aging on Acetohexamide Reductase Activities in Liver Microsomes and Cytosol of Male Rats
- カルボニル還元酵素の単離およびその特性(発表論文抄録(1993))
- ドラッグデリバリーシステムへの超音波の利用
- Kinetics of Befunolol Reductase from Rabbit Liver
- Purification and Characterization of Befunolol Reductase from Rabbit Liver
- ソフトゼラチンカプセルからの塩酸メクリジンの溶出性及び吸収挙動
- Further Studies on Reductive Metabolism of Acetohexamide in Heart
- Effect of pH Small Inorganic Ions on Binding of Sulfadimethoxine and Sulfaphenazole to Human Serum Albumin Measured by Circular Dichroism
- スルファジメトキシンの腸管吸収に及ぼす血清蛋白結合の置換効果
- Study on the Binding of Dicumarol to α_1-Acid Glycoprotein Using Circular Dichroism Spectroscopy
- 7-Alkylaminocoumarin-4-acetic Acids as Fluorescent Probe for Studies of Drug-Binding Sites on Human Serum Albumin
- Interaction of the Fluorescent Probe 7-Anilino-4-methylcoumarin-3-acetic Acid with α-Globulin
- Interaction between Methacycline and Human Serum Albumin
- X-RAY CRYSTALLOGRAPHIC DETERMINATION OF THE ABSOLUTE CONFIGURATION OF (+) FLURBIPROFEN UTILIZING β-CYCLODEXTRIN COMPLEXATION
- CRYSTAL AND MOLECULAR STRUCTURE OF 2 : 2 (±) FLURBIPROFEN-β-CYCLODEXTRIN COMPLEX
- Effect of Oral Multiple-Dose Administration of Anti-inflammatory Flurbiprofen Chimera Drug on Gastric Lesion, Other Toxicities and Disposition Kinetics
- Enhancement of Oral Bioavailability of Spironolactone by β- and γ-Cyclodextrin Complexations
- Determination of Barnidipine in Human Serum and Dog Plasma by HPLC with Electrochemical Detection
- 家兎におけるフロセミドの腎排泄に及ぼす抱水クロラールの影響
- Improvement of Dissolution Characteristics and Chemical Stability of Prostaglandin E_1 by γ-Cyclodextrin Complexation
- Controlled-Release Preparation of Indomethacin Using Calcium Alginate Gel
- Preparation and Evaluation of a Controlled-Release Formulation of Nifedipine Using Alginate Gel Beads
- Stereoselective Disposition of Pranoprofen, a Nonsteroidal Antiinflammatory Drug, in Rabbits
- Electrochemical Oxidation of Chlorpromazine-Cyclodextrin Inclusion Complex
- 家兎におけるスルフイソキサゾールの体内動態に及ぼすサリチル酸とサリチルアミドの影響
- Studies on Metabolic Reduction of Befunolol in Rabbit Liver and Kidney
- Characterization of Binding Site of Uremic Toxins on Human Serum Albumin
- Evaluation of Low-Molecular Gelatin as a Pharmaceutical Additive for Rapidly Absorbed Oral Dosage Formulation
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XVIII. Differential Effects of Oral and Rectal Administration of Chloral Hydrate on the Gastrointestinal Absorption of Sulfisoxazole in Rabbits
- Effects of β- and γ-Cyclodextrins on Release of Betamethasone from Ointment Bases
- Syntheses and Properties of 3-Hydroxy-4,6-dimethylpyrrolo [3,2-d] pyrimidine-5,7 (4H, 6H)-dione (9-Hydroxy-9-deazatheophylline) Derivatives
- New Fluorescence Probes for Drug-Albumin Intereaction Studies
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XIX. Binding of Acetohexamide and Its Major Metabolite, (-)-Hydroxyhexamide, to Human Serum Albumin
- 吸収排泄におよぼす医薬品の併用効果(第7報) : In Vitroにおけるサルファ剤の抗菌活性におよぼすタンパク結合の影響
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. VI. Effect of Protein Binding on Membrane Permeability of Sulfonamides
- 吸収排泄におよぼす医薬品の併用効果(第3報)In Vitroにおけるスルファジメトキシンの抗菌活性におよぼす非ステロイド系抗炎症剤とN^4-アセチルスルファジメトキシンの効果
- Effects of Simultaneous Administration of Drugs on Absorption and Excretion. I. Effect of Phenylbutazone on Absorption and Excretion of Sodium Cyclamate in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XVII. In Vivo Protein Binding Interaction between Sulfamethoxazole and Chloral Hydrate in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XI. Effect of Diphenhydramine on Sulfisomidine Absorption in Rabbits
- 吸収排泄におよぼす医薬品の併用効果(第9報)家兎におけるサルファ剤の血中濃度に及ぼすサリチル酸の影響
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. VIII. Effect of Plasma-Protein Binding Displacement on the Intestinal Absorption of Sulfonamides in Rabbits
- Effects of Simultaneous Administration of Drugs on Absorption and Excretion. V. Effect of Phenylbutazone on Antibacterial Activity and Distribution of Sulfadimethoxine in Rabbits
- Effects of Simultaneous Administration of Drugs on Absorption and Excretion. IV. Effect of Salicylic Acid on Antibacterial Activity and Distribution of Sulfadimethoxine in Rabbits
- Effects of Simultaneous Administration of Drugs on Absorption and Excretion. II. Effects of Non-steroidal Anti-inflammatory Drugs on Absorption and Excretion of Sulfadimethoxine in Rabbits
- Inclusion Complexation of Barbiturates with β-Cyclodextrin in Aqueous Solution. I. Spectroscopic Study on the Mode of Interaction
- Enhancement of Dissolution Rates of Several Drugs by Low-Molecular Chitosan and Alginate
- ラットの肝臓及び腎臓におけるアセトヘキサミドの還元的代謝
- In Vitro におけるアセトヘキサミドの還元的代謝に及ぼす各種薬物の影響
- METABOLIC REDUCTION OF ACETOHEXAMIDE BY RABBIT TISSUES
- Enhancement of the Dissolution Rates of Poorly Water-Soluble Drugs by Water-Soluble Gelatin
- In Vitro and in Situ Models for the Prediction of in Vivo Absorption Behavior of Sulfonamides Following Dissolution
- Effects of Cyclodextrins on the Hydrolysis of Prostacyclin and Its Methyl Ester in Aqueous Solution
- Interaction of Barbituric Acid Derivatives with Chloral Hydrate
- 家兎におけるスルフイソミジンの消化管吸収に及ぼすアルミニウムイオンの影響
- 支部大会の充実を(活気ある支部活動)
- Asymmetric Induction Reactions. VII. Palladium-Catalyzed Asymmetric α-Allylations of Carbonyl Compounds Using Chiral Sulfonamides as Chiral Ligands
- 新規な4量体カルボニル還元酵素(DHRS4)に及ぼす各種植物成分の影響