Enhancement of Dissolution Rates of Several Drugs by Low-Molecular Chitosan and Alginate
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概要
- 論文の詳細を見る
The dissolution behaviors of acidic, basic and neutral drugs from kneaded mixtures with low-molecular chitosan or alginate (LM chitosan or LM alginate) have been studied in comparison with that of the drug alone. The results revealed a significant increase of dissolution rate of drugs from kneaded mixtures. Although essentially no interaction of any drug with LM chitosan or LM alginate was observed in an aqueous solution, changes of drug crystals in the kneaded mixtures were apparent. In addition, the contact angle of kneaded mixtures was obviously reduced in comparison with that of the corresponding drug powder and physical mixture.Thus, the enhanced dissolution rate of kneaded mixtures may be due to improvement of wettability and to changes of the crystallinity, microcrystal size and shape.
- 公益社団法人日本薬学会の論文
- 1990-01-25
著者
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小田切 優樹
熊本大院・薬
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小田切 優樹
Faculty of Pharmaceutical Science, Kumamoto University
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今井 輝子
Faculty of Pharmaceutical Sciences, Kumamoto University
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白石 澄廣
Faculty of Pharmaceutical Sciences, Kumamoto University
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白石 澄廣
Faculty Of Pharmaceutical Sciences Kumamoto University
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荒平 光利
Faculty Of Pharmaceutical Sciences Kumamoto University
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白石 澄廣
Research Laboratories, Morishita Pharmaceutical Co., Ltd.,
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