Contribution of N^4-Acetylsulfadimethoxine to the Interaction of Sulfadimethoxine with Ketoprofen in Rabbits(Pharmaceutical)

概要

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The contribution of N^4-acetylsulfadimethoxine (N^4-AcSDM), a major metabolite of sulfadimethoxine (SDM), to the serum protein binding and pharmacokinetic interactions between SDM and ketoprofen (KPF) was investigated in rabbits. When SDM and KPF were intravenously co-administered, KLPF indirectly reduced the serum protein binding of SDM through the interaction of KPF with N^4-AcSDM, and significantly increased the total body clearance (Cl_<tot>) and steady-state volume of distribution (V_<dss>) of SDM. In addition, the co-administration of N^4-AcSDM was found to increase Cl_<tot> and Fdss of SDM. These results indicate that N^4-AcSDM contributes substantially to the serum protein binding and pharmacokinetic interactions between SDM and KPF in rabbits.
社団法人日本薬学会の論文
1987-03-25