吸収排泄におよぼす医薬品の併用効果(第3報)In Vitroにおけるスルファジメトキシンの抗菌活性におよぼす非ステロイド系抗炎症剤とN^4-アセチルスルファジメトキシンの効果

概要

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The inhibitory effect of non-steroidal anti-inflammatory agents on the binding of sulfadimethoxine (SDM) with bovine serum albumin (BSA) in vitro was determined by equilibrium dialysis method. The effect of non-steroidal anti-inflammatory agents on antibacterial activity of SDM in the presence of BSA was analyzed by thin-layer paper disc method and compared with the results obtained from the former. The effect of sulfadimethoxine N_4-acetate, which is one metabolite of SDM, on the binding of SDM with BSA, and antibacterial activity of SDM in the presence of BSA was tested by the same method. These studies revealed the following : (1) The displacing activity of non-steroidal anti-inflammatory agents on the binding of SDM with BSA decreased in the order of phenylbutazone, salicylic acid, mefenamic acid, bucolome, indomethacin, and benzydamine. (2) Antibacterial activity of SDM was markedly reduced by the addition of BSA. (3) Antibacterial activity of SDM that decreased in the presence of BSA was recovered by the addition of non-steroidal anti-inflammatory agents. This activity decreased in the order of phenylbutazone, salicylic acid, bucolome, indomethacin, and benzydamine. (4) Sulfadimethoxine N^4-acetate also inhibited the binding of SDM with BSA and increased this reduced antibacterial activity of SDM.
公益社団法人日本薬学会の論文
1973-09-25