スルファジメトキシンの腸管吸収に及ぼす血清蛋白結合の置換効果

概要

論文の詳細を見る
The displacing effect of serum protein binding on the intestinal absorption of sulfadimethoxine (SDM) in rabbits was examined by using N^4-acetylsulfadimethoxine (N^4-AcSDM), a major metabolite of SDM, as a displacing drug. N^4-AcSDM markedly decreased the in vitro serum protein binding of SDM, while many drugs including phenylbutazone and salicylic acid did not display such a marked decreasing-effect. The intravenous administration of N^4-AcSDM clearly decreased the in situ intestinal absorption of SDM. As expected, the intravenously administered N^4-AcSDM enhanced the serum concentration of unbound SDM in the common jejunal vein. However, the intravenously administered N^4-AcSDM caused no change in the transfer of SDM across the intestinal membrane. These results indicate that the displacement of serum protein binding can become one of factors decreasing the intestinal absorption of SDM.
社団法人日本薬学会の論文
1989-01-25