In Vitro におけるアセトヘキサミドの還元的代謝に及ぼす各種薬物の影響

概要

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The effects of various drugs on the metabolic reduction of acetohexamide were investigated by using the cytosols of the rabbit liver, kidney and heart. Most of nonsteroidal anti-inflammatory drugs inhibited the acetohexamide reduction in these three tissues. Especially, indomethacin, diclofenac, protizinic acid and flufenamic acid gave powerful inhibitions. Ketone-containing drugs including warfarin also inhibited the acetohexamide reduction in both the liver and kidney; acetohexamide reduction in the heart was inhibited by only warfarin. On the other hand, drugs which inhibited hepatic microsomal enzyme, and (-)-hydroxyhexamide, a major metabolite of acetohexamide, had no effect on acetohexamide reducing activities of these three tissues.
公益社団法人日本薬学会の論文
1988-01-25