Species Difference in the in Vitro Metabolic Reduction of Acetohexamide
スポンサーリンク
概要
- 論文の詳細を見る
Species difference in the in vitro metabolic reduction of acetohexamide, an oral antidiabetic drug, was investigated using the rabbit, guinea pig, hamster, rat and mouse. The rabbit exhibited the highset acetohexamide reductase activity in cytosol of the liver and kidney among the species tested. The sensitivities to specific inhibitors of cytosolic acetohexamide reductase in the liver and kidney of the rabbit were different from those of the rat. Furthermore, species difference in acetohexamide reductase activity was found in the microsomes of the liver and kidney; only the rat and guinea pig showed significant activity.
- 社団法人日本薬学会の論文
- 1988-10-25
著者
-
今村 順茂
Faculty of Pharmaceutical Sciences, Kumamoto University
-
今村 順茂
Faculty Of Pharmaceutical Sciences Kumamoto University
-
小嶋 祐一郎
Faculty of Pharmaceutical Sciences, Kumamoto University
-
小田切 雅樹
Faculty of Pharmaceutical Sciences, Kumamoto University
-
小田切 雅樹
Faculty Of Pharmaceutical Sciences Kumamoto University
-
小嶋 祐一郎
Faculty Of Pharmaceutical Sciences Kumamoto University
関連論文
- Characterization of Binding Sites for Sulfadimethoxine and Its Major Metaboite, N^4-Acetylsulfadimethoxine, on Human and Rabbit Serum Albumin
- Species Difference in the in Vitro Metabolic Reduction of Acetohexamide
- Inclusion Complex of Acetohexamide with β-Cyclodextrin and Its Hypoglycemic Activity in Rabbit
- Contribution of N^4-Acetylsulfadimethoxine to the Interaction of Sulfadimethoxine with Ketoprofen in Rabbits(Pharmaceutical)
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XVI. Effect of Probenecid on Plasma Protein Binding of Sulfadimethoxine in Fast and Slow Acetylator Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XIII. Effect of Salicylic Acid on the Absorption, Distribution and Elimination of Carbutamide in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XII. Effect of Salicylic Acid on Hypoglycemic Activity and Blood Concentration of Carbutamide in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. X. Plasma Protein Binding of Carbutamide in Rabbits
- Mechanism of Inhibition of Carbonyl Reductase from Rabbit Kidney by Phenylbutazone
- Influence of Aging on Acetohexamide Reductase Activities in Liver Microsomes and Cytosol of Male Rats
- Kinetics of Befunolol Reductase from Rabbit Liver
- Purification and Characterization of Befunolol Reductase from Rabbit Liver
- Further Studies on Reductive Metabolism of Acetohexamide in Heart
- Effect of pH Small Inorganic Ions on Binding of Sulfadimethoxine and Sulfaphenazole to Human Serum Albumin Measured by Circular Dichroism
- Study on the Binding of Dicumarol to α_1-Acid Glycoprotein Using Circular Dichroism Spectroscopy
- Studies on Metabolic Reduction of Befunolol in Rabbit Liver and Kidney
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XVIII. Differential Effects of Oral and Rectal Administration of Chloral Hydrate on the Gastrointestinal Absorption of Sulfisoxazole in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XIX. Binding of Acetohexamide and Its Major Metabolite, (-)-Hydroxyhexamide, to Human Serum Albumin
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. VI. Effect of Protein Binding on Membrane Permeability of Sulfonamides
- Effects of Simultaneous Administration of Drugs on Absorption and Excretion. I. Effect of Phenylbutazone on Absorption and Excretion of Sodium Cyclamate in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XVII. In Vivo Protein Binding Interaction between Sulfamethoxazole and Chloral Hydrate in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XI. Effect of Diphenhydramine on Sulfisomidine Absorption in Rabbits
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. VIII. Effect of Plasma-Protein Binding Displacement on the Intestinal Absorption of Sulfonamides in Rabbits
- Effects of Simultaneous Administration of Drugs on Absorption and Excretion. V. Effect of Phenylbutazone on Antibacterial Activity and Distribution of Sulfadimethoxine in Rabbits
- Effects of Simultaneous Administration of Drugs on Absorption and Excretion. IV. Effect of Salicylic Acid on Antibacterial Activity and Distribution of Sulfadimethoxine in Rabbits
- Effects of Simultaneous Administration of Drugs on Absorption and Excretion. II. Effects of Non-steroidal Anti-inflammatory Drugs on Absorption and Excretion of Sulfadimethoxine in Rabbits
- ラットの肝臓及び腎臓におけるアセトヘキサミドの還元的代謝
- In Vitro におけるアセトヘキサミドの還元的代謝に及ぼす各種薬物の影響
- METABOLIC REDUCTION OF ACETOHEXAMIDE BY RABBIT TISSUES