Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XIX. Binding of Acetohexamide and Its Major Metabolite, (-)-Hydroxyhexamide, to Human Serum Albumin
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概要
- 論文の詳細を見る
The binding of acetohexamide and its major metabolite, (-)-hydroxyhexamide, to human serum albumin (HSA) was examined by using the equilibrium dialysis method. (-)-Hydroxyhexamide was isolated from the urine of rabbits after oral administration of acetohexamide. The Scatchard plots suggested that acetohexamide interacts with two kinds of binding sites on HSA, whereas (-)-hydroxyhexamide interacts with only one kind of binding sites. In addition, the binding parameters obtained led us to conclude that serum protein binding of (-)-hydroxyhexamide is considerably lower than that of acetohexamide.
- 公益社団法人日本薬学会の論文
- 1985-03-25
著者
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今村 順茂
Faculty of Pharmaceutical Sciences, Kumamoto University
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今村 順茂
熊本大学薬学部
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今村 順茂
Faculty Of Pharmaceutical Sciences Kumamoto University
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小嶋 祐一郎
Faculty of Pharmaceutical Sciences, Kumamoto University
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一番ヶ瀬 尚
Faculty of Pharmaceutical Sciences, Kumamoto University
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小嶋 祐一郎
Faculty Of Pharmaceutical Sciences Kumamoto University
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一番ヶ瀬 尚
Faculty Of Pharmaceutical Sciences Kumamoto University
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