Mechanism of Inhibition of Carbonyl Reductase from Rabbit Kidney by Phenylbutazone
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概要
- 論文の詳細を見る
Phenylbutazone showed significant inhibition against the metabolic reduction of acetohexamide catalyzed by carbonyl reductase purified from rabbit kidney. Thus, the inhibitory effect of phenylbutazone was kinetically examined. Phenylbutazone was a competitive inhibitor for the enzyme with respect to NADPH, whereas it noncompetitively inhibited the enzyme activity with respect to acetohexamide. A fluorescence study revealed that phenylbutazone decreases the binding of NADPH to the free enzyme (apoenzyme). These results suggest that phenylbutazone causes the inhibition of carbonyl reductase by competing with NADPH in its coenzyme-binding domain.
- 社団法人日本薬学会の論文
- 1995-04-15
著者
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小田切 優樹
Faculty of Pharmaceutical Science, Kumamoto University
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今村 順茂
Faculty of Pharmaceutical Sciences, Kumamoto University
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今村 順茂
熊本大学薬学部
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小田切 優樹
Faculty Of Pharmaceutical Sciences Kumamoto University
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今村 順茂
Faculty Of Pharmaceutical Sciences Kumamoto University
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樋口 敏幸
熊本大学薬学部
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樋口 敏幸
Faculty of Pharmaceutical Sciences, Kumamoto University
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HIGUCHI Teruhiko
Neuropsychiatry Department, Showa University Fujigaoka Hospital
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樋口 恒彦
Waseda Univ.
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樋口 敏幸
Faculty Of Pharmaceutical Sciences Kumamoto University
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