Pyridinolcarbamateに関する生物薬剤学的研究(第1報)家兎におけるサルファ剤の腎排泄に及ぼすPyridinolcarbamate連続投与の影響

概要

論文の詳細を見る
Effect of the continuous administration of pyridinolcarbamate (Pc) on the renal excretion of sulfonamides was investigated in rabbits. The continuous Pc administration significantly decreased the renal excretion of N^4-acetylsulfanilamide and N^4-acetyl-sulfadimethoxine, which are major metabolites of sulfanilamide and sulfadimethoxine. On the other hand, continuous Pc administration did not affect the renal excretion of unchanged sulfanilamide and unchanged sulfadimethoxine. It has been known that N^4-acetylsulfanilamide and N^4-acetylsulfadimethoxine are excreted by both the glomerular filtration and tubular secretion, but unchanged sulfanilamide and unchanged sulfadimethoxine are excreted by only the glomerular filtration. Therefore, the present experimental results suggest that the continuous Pc administration inhibits the tubular secretion of N^4-acetylsulfanilamide and N^4-acetylsulfadimethoxine.
社団法人日本薬学会の論文
1978-10-25