Inclusion Complex of Acetohexamide with β-Cyclodextrin and Its Hypoglycemic Activity in Rabbit
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概要
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Inclusion complex formation of acetohexamide with β-cyclodextrin in water and in solid state was ascertained by solubility method, circular dichroism spectroscopy, and powder X-ray diffractometry. A solid complex of acetohexamide with β-cyclodextrin in 1 : 2 molar ratio was prepared, and its dissolution behavior in water and hypoglycemic activity in rabbit were examined. Improved dissolution characteristic of acetohexamide by inclusion complexation resulted in potentiation of the reduction in blood glucose levels in rabbit, which may be due to the increase in absorption of the drug.
- 社団法人日本薬学会の論文
- 1979-02-25
著者
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平山 文俊
Faculty Of Pharmaceutical Sciences Sojo University
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平山 文俊
Faculty Of Pharmaceutical Sciences Kyushu University
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今村 順茂
Faculty of Pharmaceutical Sciences, Kumamoto University
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上釜 兼人
Faculty Of Pharmaceutical Sciences Kumamoto University
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松尾 直樹
Faculty of Pharmaceutical Sciences, Kumamoto University
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山口 辰哉
Faculty Of Pharmaceutical Sciences Kumamoto University
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今村 順茂
Faculty Of Pharmaceutical Sciences Kumamoto University
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一番ヶ瀬 尚
Faculty of Pharmaceutical Sciences, Kumamoto University
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一番ケ瀬 尚
熊本大薬
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一番ヶ瀬 尚
Faculty Of Pharmaceutical Sciences Kumamoto University
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