Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XII. Effect of Salicylic Acid on Hypoglycemic Activity and Blood Concentration of Carbutamide in Rabbits
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概要
- 論文の詳細を見る
The effect of salicylic acid on the hypoglycemic activity and blood carbutamide concentration after oral administration of carbutamide was investigated in rabbits. Salicylic acid was found to enhance the hypoglycemic activity, while on the other hand, it was found to deorease the blood carbutamide concentration. Salicylic acid markedly decreased the in vivo binding of carbutamide to rabbit plasma proteins, and caused a significant increase in the plasma concentration of unbound carbutamide, despite a significant decrease in the plasma concentration of total carbutamide. These results lead us to conclude that the displacement of carbutamide from its plasma protein binding sites by salicylic acid produces both the enhanced hypoglycemic activity and the decreased blood carbutamide concentration.
- 社団法人日本薬学会の論文
- 1982-05-25
著者
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今村 順茂
Faculty of Pharmaceutical Sciences, Kumamoto University
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有森 和彦
Faculty Of Pharmaceutical Sciences Kumamoto University
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今村 順茂
Faculty Of Pharmaceutical Sciences Kumamoto University
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一番ヶ瀬 尚
Faculty of Pharmaceutical Sciences, Kumamoto University
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園田 正信
熊本大学薬学部
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園田 正信
Faculty of Pharmaceutical Sciences, Kumamoto University
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一番ケ瀬 尚
熊本大薬
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一番ヶ瀬 尚
Faculty Of Pharmaceutical Sciences Kumamoto University
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