Improvement in Percutaneous Absorption of Prednisolone by β- and γ-Cyclodextrin Complexations(Pharmaceutical)
スポンサーリンク
概要
- 論文の詳細を見る
In vitro release characteristics of prednisolone(PD) and its β- and γ-cyclodextrin (β- and γ- CyD) complexes were investigated by using an ointment release simulator with artificial doublelayer membranes. The release of PD from hydrophilic ointment was significantly improved by β- and γ-CyD complexations. Permeation and uptake studies indicated that the enhanced release of PD from the ointment may be mainly due to the faster dissolution of PD in the base and the lower binding affinity of PD to the ointment base as a result of the CyD complexations. The percutaneous absorption of PD from hydrophilic ointment after application to the rabbit skin was also increased by CyD complexations. The in vitro and in vivo data suggest that CyDs can improve the topical bioavailability of PD.
- 社団法人日本薬学会の論文
- 1987-07-25
著者
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入江 徹美
熊本大・薬
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上釜 兼人
熊本大学 歯
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上釜 兼人
Faculty Of Pharmaceutical Sciences Kumamoto University
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有森 和彦
Faculty Of Pharmaceutical Sciences Kumamoto University
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有森 和彦
熊本大学薬学部
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入江 徹美
Faculty of Pharmaceutical Sciences, Kumamoto University
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酒井 淳
Faculty of Pharmaceutical Sciences, Kumamoto University
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正木 勝広
Faculty of Pharmaceutical Sciences, Kumamoto University
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正木 勝広
熊本大学薬学部
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Irie T
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Irie Tetsumi
Dep. Of Clinical Chemistry And Informatics Graduate School Of Pharmaceutical Sciences Kumamoto Univ.
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酒井 淳
Faculty Of Pharmaceutical Sciences Kumamoto University
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上釜 兼人
崇城大 薬
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