Riboflavin-Sensitized Photooxidation of Phenothiazines in Aqueous Solution by Laser-Irradiation
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概要
- 論文の詳細を見る
A laser-irradiation (490 nm) of the tranquilizing phenothiazines such as chlorpromazine, propericiazine, prochlorperazine, and promethazine in the presence of riboflavin gave the corresponding sulfoxides in an acidic buffer solution (pH 4.0). Fluorescence quenching and visible absorption changes of riboflavin by the binding to phenothiazines were quantitatively treated to obtain the equilibrium constants (K_c) of the complexes. The larger the K_c values, the greater the extent of photolysis was observed. Riboflavin-sensitized photooxidation was discussed on the basis of the complex formation between riboflavin and phenothiazines.
- 社団法人日本薬学会の論文
- 1979-04-25
著者
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入江 徹美
熊本大・薬
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平山 文俊
Faculty Of Pharmaceutical Sciences Sojo University
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平山 文俊
Faculty Of Pharmaceutical Sciences Kyushu University
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上釜 兼人
Faculty Of Pharmaceutical Sciences Kumamoto University
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米田 文郎
Faculty of Pharmaceutical Sciences, Kyoto University
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入江 徹美
Faculty of Pharmaceutical Sciences, Kumamoto University
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Irie T
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Irie Tetsumi
Dep. Of Clinical Chemistry And Informatics Graduate School Of Pharmaceutical Sciences Kumamoto Univ.
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米田 文郎
Faculty Of Pharmaceutical Sciences Kyoto University
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