Enhanced Absorption of Phenobarbital from Suppositories containing Phenobarbital-β-Cyclodextrin Inclusion Complex
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概要
- 論文の詳細を見る
Phenobarbital was dissolved faster from a β-cyclodextrin complex than from phenobarbital powder, and it was released faster from suppositories containing its β-cyclodextrin complex than from those containing phenobarbital powder. After rectal administration of the suppository containing the β-cyclodextrin complex to rabbits, the blood concentration of the drug was higher than that following administration of the phenobarbital suppository. Since β-cyclodextrin tended to retard absorption of the drug in solution from the rectum, enhanced absorption of the drug from the complex was attributed to fast release from the suppository due to rapid dissolution.
- 公益社団法人日本薬学会の論文
- 1982-04-25
著者
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上釜 兼人
Faculty Of Pharmaceutical Sciences Kumamoto University
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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岩奥 玲子
熊本大学医学部附属病院薬剤部
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岩奥 玲子
Department of Pharmaceutical Services, Kumamoto University Hospital
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上釜 兼人
崇城大 薬
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有森 和彦
Department of Pharmacy, Kumamoto University Hospital
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中野 眞汎
Department of Clinical Pharmaceutics, Graduate School of Pharmaceutical Sciences, University of Shizuoka
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