Preparation and Evaluation of Sustained Release Tablets Prepared with α-Starch(Pharmaceutical,Chemical)
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概要
- 論文の詳細を見る
A compressed tablet prepared from a-starch adsorbed water from the release medium and formed a gel, starting from the tablet surface. Theophylline was released slowly through the gelled layer. Release rates of theophylline from tablets prepared with a-starches from different sources were different. Release rates of theophylline from the tablets were faster in an acidic medium than in a neutral medium. The release rate of theophylline was faster in a medium containing α-amylase than in a medium without the enzyme. Salivary levels were lower but were sustained for longer following oral administration of an α-starch tablet than those after administration of.a rapidly dissolving tablet.
- 社団法人日本薬学会の論文
- 1987-10-25
著者
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猪爪 信夫
北海道薬科大学薬物治療学分野
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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猪爪 信夫
熊本大学医学部附属病院薬剤部
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猪爪 信夫
Department of Pharmaceutical Services, Kumamoto University Hospital
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中園 直子
熊本大学医学部附属病院薬剤部
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中園 直子
Department of Pharrnaceutical Services, Kumamoto University Hospital
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中野 眞汎
Department of Clinical Pharmaceutics, Graduate School of Pharmaceutical Sciences, University of Shizuoka
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