フロセミドの体内動態と作用に及ぼす食事の影響

概要

論文の詳細を見る
The purpose of this study is to investigate the influence of food on pharmacokinetics and phartnacodynamics of furosemide after oral administration of a tablet (40mg) 30 minutes before or after breakfast to three healthy male volunteers by measuring plasma concentrations and excretion rates in urine. The results showed that the pharmacokinetic parameters C_max, t_max, MRT_0-8 (mean residence time) and AUC_0-8 after administration of furosemide before breakfast were significantly different from those after breakfast. Higher volume of urine was observed immediately after oral administration of furosemide before breakfast than that after breakfast, while cumulative volume of urine with in a 24-hour period was not significantly different between those before and after breakfast. Therefore, old-age patients with hypertension should be careful when they take furosemide before a meal because of the sudden diuretic effect of furosemide.
日本医療薬学会の論文
1988-02-20