消化管内細菌によるフルニトラゼパムの還元

概要

論文の詳細を見る
The possibility of degradation of flunitrazepam with fresh stool was investigated. After the combination of flunitrazepam with sterilized broth (pH 7.1), 1% (pH 6.7) or 8% (pH 6.3) sterilized stool culture without further anaerobic precautions, the drug did not degrade in the incubation mixture. This indicates that the drug did not react with the components of broth and stool cultures and was stable at these pH values. On the other hand, after the combination of the drug with 1% or 8% human faecal contents in a broth, the drug disappeared rapidly in the incubation mixture in proportion to stool concentrations. The metabolite was identified to be 7-aminoflunitrazepam by high performance liquid chromatography (HPLC). The degradation patterns of flunitrazepam were followed by HPLC.
社団法人日本薬学会の論文
1985-12-25