薬物血中濃度モニタリング患者における小児薬用量の解析

概要

論文の詳細を見る
The relation of pediatric doses to body weight and body surface area was examined in patients whose plasma concentrations of phenobarbital, phenytoin, sodium valproate, carbamazepine, and theophylline were monitored. There existed definite correlations between the dose and body weight, or between the dose and body surface area. Among five drugs, the best correlation was obtained in theophylline. Moreover, the dose was correlated better with body surface area than with body weight. The doses per body weight of phenytoin and theophylline were significantly greater in children with age under 15 years old than in adults over 15 years old, and those of the other drugs also showed a similar tendency. On the other hand, there was no difference in the dose per body surface area between children and adults. The (plasma concentration/dose per body weight) ratios of phenobarbital, phenytoin and theophylline were significantly lower in children than in adults. Consequently, it seems that the doses in patients under therapeutic drug monitoring correlate better with body surface area than with body weight.
日本医療薬学会の論文
1991-08-20