Release Characteristics of a Free Polyunsaturated Fatty Acid from an Oily Lymphographic Agent

概要

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The release profiles of a free polyunsaturated fatty acid, α-linolenic acid, from solutions in an oily lymphographic agent Lipiodol-Ultra-Fluid^<[○!R]> (Lipiodol), to rabbit and human plasma, phosphate buffer solution (PBS), and PBS containing bovine serum albumin (BSA) were examined in vitro. The times required for 50% release of α-linolenic acid from Lipiodol were about 1 and 1.5 h in the rabbit and human plasma, respectively. Although only a slight amount of α-linolenic acid was released from Lipiodol to PBS after 24 h incubation at 37℃, release was markedly enhanced by the addition of BSA to PBS. The amount of α-linolenic acid released from Lipiodol into PBS containing 5% BSA increased as the α-linolenic acid content in Lipiodol was increased. In all experiments, the release had stopped before all α-linolenic acid had been released. The prolongation of α-linolenic acid release from Lipiodol is considered a requisite for a selective anticancer effect of Lipiodol containing a free fatty acid on liver cancer.
社団法人日本薬学会の論文
1990-10-25