Change in Apparent Permeability of Iodine in the Presence of Polyvinylpyrrolidone

概要

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The permeation patterns of iodine through a dimethylpolysiloxane membrane were studied using an all-glass permeation cell. The permeability of iodine was greater from solvents in which iodine is less soluble. In the presence of polyvinylpyrrolidone (PVP), the permeability decreased with storage period and with increasing amount of PVP. The permeability of iodine from a solution containing PVP decreased with increasing storage temperature prior to permeation studies. When iodide ions were added to the PVP-iodine system, the permeability of iodine became less than that in the absence of iodide ions. Further, the storage-time dependent decrease in permeability of iodine was much less in the presence of iodide ions. These observations suggest the decrease in the amount of permeable iodine in the system with time. This phenomenon is attributed to the acceleration of the hydrolysis of iodine in the presence of PVP.
公益社団法人日本薬学会の論文
1978-03-25