Solubilities of Antipyrine Derivatives in Water and Non-polar Solvents
スポンサーリンク
概要
- 論文の詳細を見る
The solubility of antipyrine derivatives has been determined in water and several organic solvents. Aminopyrine and isopropylantipyrine exhibited a solubility minimum near 25° and 15°, respectively, corresponding to a zero heat of solution. Hildebrand's solubility parameters were assigned to these compounds. The experimental results in benzene and ethylene chloride were compared with the theoretical solubility calculated from the Hildebrand's equation for regular solutions at 25°. Fair agreement was found for aminopyrine and isopropylantipyrine in benzene, but the agreement was not close for antipyrine and 4-aminoantipyrine in benzene and ethylene chloride. These discrepancies are the reflection of specific solute-solvent interaction.
- 社団法人日本薬学会の論文
- 1974-10-25
著者
-
有田 隆一
Faculty of Pharmatical Science, Mukogawa Women's University
-
森本 雍憲
Faculity Of Pharmaceutical Sciences Josai University
-
堀 了平
Faculty of Pharmaceutical Sciences, Hokkaido University
-
有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
-
有田 隆一
Faculty Of Pharmaceutical Sciences Mukogawa Womenus University
-
堀 了平
Department Of Pharmacy Kyoto University Hospital
関連論文
- Determination of Triethylenetetramine in Plasma of Patients by High-Performance Liquid Chromatography
- Transformation and Excretion of Drugs in Biological Systems. IX. Interactions between Sulfinpyrazone and Sulfonamides, and between Oxyphenbutazone and Sulfonamides in Dogs
- Transformation and Excretion of Drugs in Biological Systems. VIII. Interactions between 5-n-Butyl-1-cyclohexyl-2,4,6-trioxoperhydro-pyrimidine and Sulfonamides in Dogs
- Transformation and Excretion of Drugs in Biological Systems. VII. Effect of Biotransformation on Renal Excretion of Sulfonamides
- Transformation and Excretion of Drugs in Biological Systems. VI. Correlation between Renal Excretion and Biotransformation of Sulfisomidine and Sulfamethizole
- Transformation and Excretion of Drugs in Biological Systems. V. Correlation between Renal Excretion and Biotransformation of Sulfadimethoxine
- Disintegration Test to Measure Lot-to-Lot Variations of Vaginal Tablets
- Fibrinogen Microspheres as Novel Drug Delivery Systems for Antitumor Drugs
- Dispersion State of Protein-stabilized Magnetic Emulsions
- Pulmonary Uptake of Liposomal Phosphatidylcholine upon Intratracheal Administration to Rats
- Effect of Pyrazolone Derivatives on the Critical Micelle Concentration of Ionic Surfactants
- Solubilities of Antipyrine Derivatives in Water and Non-polar Solvents
- In Vitro-in Vivo Correlation of Percutaneous Absorption : Isosorbide Dinitrate and Morphine Hydrochloride
- Estimation of Blood Concentration of Drugs after Topical Application from in Vitro Skin Permeation Data. II. : Approach by Using Diffusion Model and Compartment Model
- Estimation of Blood Concentration of Drugs after Topical Application from in Vitro Skin Permeation Data. I. : Prediction by Convolution and Confirmation by Deconvolution
- Trichloroethyl Phosphate のラット消化管内における加水分解挙動
- パルミチン酸クロラムフェニコールー結晶セルロース混合粉砕物の物理化学的性質と消化管吸収
- Release of Clonidine Hydrochloride from Pressure-Sensitive Adhesive Matrices Prepared by Emulsion-Type Acrylate Polymers
- Detoxication Capacity of a Multiple (w/o/w) Emulsion for the Treatment of Drug Overdose. II. Detoxication of Quinine Sulfate with the Emulsion in the Gastro-intestinal Tract of Rabbits
- Detoxication Capacity of a Multiple (w/o/w) Emulsion for the Treatment of Drug Overdose : Drug Extraction into the Emulsion in the Gastro-intestinal Tract of Rabbits
- 溶解性,吸収性を改良した新しいジフェニルヒダントイン剤 (抗けいれん剤の発達薬理)
- Drug-carrier Property of Albumin Microspheres in Chemotherapy. II. Preparation and Tissue Distribution in Mice of Microsphere-entrapped 5-Fluorouracil
- Solubility Characteristics of Weak Bases and Their Hydrochloride Salts in Hydrochloric Acid Solutions
- Drug-carrier Property of Albumin Microspheres in Chemotherapy. IV. Antitumor Effect of Single-shot or Multiple-shot Administration of Microsphere-entrapped 5-Fluorouracil on Ehrlich Ascites or Solid Tumor in Mice
- Transformation and Excretion of Drugs in Biological Systems. XI. Renal Excretion Mechanisms of Sulfonamides in Rabbits. (3)
- Transformation and Excretion of Drugs in Biological Systems. X. Renal Excretion Mechanisms of Sulfonamides in Rabbits. (2)
- Transformation and Excretion of Drugs in Biological Systems. I. Renal Excretion Mechanisms of Sulfonamides. (I)
- Feasibility of Use of Several Cardiovascular Agents in Transdermal Therapeutic Systems with l-Menthol-Ethanol System on Hairless Rat and Human Skin
- Prodrugs of 2', 3'-Dideoxyinosine (DDI) : Improved Oral Bioavailability via Hydrophobic Esters
- 抗酸化剤の研究 : (第4報)ω, ω′-Bis-p-aminophenol誘導体の合成ならびにその抗酸化性
- Sustained Release of Dibucaine from Konjac Gels after Rectal Administration to Rats
- Effect of Formulation Additives on the Dissolution Behavior of Tetracycline Antibiotics
- Solution and Partition Behaviors of Colchicine
- Fluorometric Determination of Cephalexin in Urine
- The Effect of Charges on Permeabilities of Drugs through Collagen Membranes
- Effect of Additives on the Polymorphic Transformation of Chlortetracycline Hydrochloride Crystals
- Polymorphic Transformation of Chlortetracycline Hydrochloride Crystals Studied by Infrared Spectrophotometric Method
- A Comparison of Solubility Characteristics of Free Bases and Hydrochloride Salts of Tetracycline Antibiotics in Hydrochloric Acid Solutions
- Effect of Crystal Forms on the Dissolution Behavior and Bioavailability of Tetracycline, Chlortetracycline, and Oxytetracycline Bases
- Sustained Release of Theophylline from Konjac Gels
- The Permeation of Benzodiazepines through Synthetic Membranes
- Interactions of Aluminum, Magnesium, and Calcium Ions with Nalidixic Acid
- Spectrophotometric Studies on Accelerated Hydrolysis of Iodine In the Presence of Polyvinylpyrrolidone
- Change in Apparent Permeability of Iodine in the Presence of Polyvinylpyrrolidone
- Analysis of Permeation Profiles of Drugs from Systems containing Micelles
- Controlled Release of Butamben (Buryl p-aminobenzoate) through Silicone Membrane by Means of Complexation and Micellar Solubilization
- Controlled Drug Permeation. II. Comparative Permeability and Stability of Butamben and Benzocaine
- Physical Properties of Pyrimidine and Purine Antimetabolites. II. Permeation of 5-Fluorouracil and 1-(2-Tetrahydrofuryl)-5-fluorouracil through Cellophane, Collagen, and Silicone Membranes
- Physical Properties of Pyrimidine and Purine Antimetabolites. I. The Effects of Salts and Temperature on the Solubility of 5-Fluorouracil, 1-(2-Tetrahydrofuryl)-5-fluorouracil, 6-Mercaptopurine, and Thioinosine
- Metabolism of Thiamphenicol and Comparative Studies of Its Urinary and Biliary Excretion with Chloramphenicol in Various Species
- Absorption and Excretion of Drugs. XXXIV. An Aspect of the Mechanism of Drug Absorption from the Intestinal Tract in Rats
- Absorption and Excretion of Drugs. XXXIII. The Correlation between the Absorption of Barbituric Acid Derivatives from the Rat Small Intestine and Their Binding to the Mucosa
- Absorption and Excretion of Drugs. XXXII. Absorption of Barbituric Acid Derivatives from Rat Small Intestine.
- Absorption and Excretion of Drugs. XXXI. On the Relationship between Partition Coefficients and Chemical Structures of Barbituric Acid Derivatives.
- Absorption and Excretion of Drugs. XXX. Absorption of Barbituric Acid Derivatives from Rat Stomach.
- Enhanced Transdermal Delivery of Zidovudine in Rats and Human Skin
- Further Investigation on the Interaction of Sulfonamides with Non-steroidal Anti-inflammatory Agents in Dogs
- Dissolution Behavior and Gastrointestinal Absorption of Sulfamethoxazole from Sulfamethoxazole-Polyvinylpyrrolidone Coprecipitates
- Dissolution Behavior and Gastrointestinal Absorption of Dicumarol from Solid Dispersion Systems of Dicmarol-Polyvinylpyrrolidone and Dicumarol-β-Cyclodextrin
- Influence of Dietary Components on the Bioavailability of Phenytoin
- Dissolution Mechanisms of Drug-Polyvinylpyrrolidone Coprecipitates in Aqueous Solution
- Effects of Macromolecular Additives and Urea on the Intestinal Absorption of Acetaminophen in Rats
- Dissolution Behaviors and Gastrointestinal Absorption of Tolbutamide in Tolbutamide-Polyvinylpyrrolidone Coprecipitate
- Dissolution Behaviors and Gastrointestinal Absorption of Phenytoin in Phenytoin-Polyvinylpyrrolidone Coprecipitate
- Duration and Reversibility of the Penetration-Enhancing Effect of Azone
- Influence of Isosorbide DInitrate Concentration on Its Skin Permeability from Adhesive Matrix Devices
- Prediction of Skin Permeability of Drugs. I. Comparison with Artificial Membrane
- Method for Optical Resolution of Racemic Homochlorcyclizine and Comparison of Optical Isomers in Antihistamine Activity and Pharmacokinetics
- Studies on the Pharmaceutical Potentiation of Drugs. I. p-Aminosalicylic Acid Derivatives.
- Calculation of Skin Permeability Coefficient for Ionized and Unionized Species of Indomethacin
- Skin Permeability of Water-Soluble Drugs
- Effect of Several Enhancers on the Skin Permeation of Water-Soluble Drugs
- Application of the Cloud Point Method to the Study of the Interaction of Polyvinylpyrrolidone with Some Organic Compounds in Aqueous Solution
- テトラサイクリンの数種の固相の物性と消化管吸収
- Effect of Polymorphism on the Dissolution Behavior and Gastrointestinal Absorption of Chlortetracycline Hydrochloride
- Studies on Percutaneous Absorption of Drugs. III. Percutaneous Absorption of Drugs through Damaged Skin
- Chemical Assay of Thiamphenicol and Chloramphenicol
- Studies on Percutaneous Absorption of Drugs. II. Time-Course of Cutaneous Reservoir of Drugs
- Transformation and Excretion of Drugs in Biological Systems. IV. Reabsorption of Biliary Metoclopramide-N^4-glucuronide and -N^4-sulfonate from Rabbit Intestine
- Transformation and Excretion of Drugs in Biological Systems. III. Separatory Determination of Metoclopramide and Its N^4-Glucuronide and N^4-Sulfonate in Rabbit Urine and Bile
- Effect of Solvents on the Permeation of Nicardipine Hydrochloride through the Hairless Rat Skin(Pharmaceutical)
- 抗酸化剤の研究(第3報) : ω, ω′-Bis(2(3 or 4)-hydroxyphenyl)alkane類およびω, ω′-Bis-(2-hydroxy-3(4 or 5)-methylphenyl)alkane類の合成ならびにその抗酸化性
- Antitumor Effect of Ethylene-Vinyl Acetate Copolymer Matrices containing 5-Fluorouracil on Ehrlich Ascites Carcinoma in Mice
- Studies on Percutaneous Absorption of Drugs. I.
- Inhibitory Effect of Polyvinylpyrrolidone on the Crystallization of Drugs
- A Comparison of Bioavailability of Free Bases and Hydrochloride Salts of Chlortetracycline, Demethylchlortetracycline, and Methacycline
- Drug-carrier Property of Albumin Microspheres in Chemotherapy. V. Antitumor Effect of Microsphere-entrapped Adriamycin on Liver Metastasis of AH 7974 Cells in Rats
- Drug-carrier Property of Albumin Microspheres in Chemotherapy. I. Tissue Distribution of Microsphere-entrapped 5-Fluorouracil in Mice
- Effect of First-Pass Metabolism on Enantioselective Pharmacokinetics after Oral Administration of (+)-, (-)- and Racemic Homochlorcyclizine to Rats
- Transformation and Excretion of Drugs in Biological Systems. II. Transformation of Metoclopramide in Rabbits
- Basic Studies on Controlled Transdermal Delivery on Nicardipine Hydrochloride Using Ethylene-Vinyl Acetate and Ethylene-Vinyl Alcohol Copolymer Membranes
- Magnetic Guidance of Ferro-colloid-entrapped Emulsion for Site-specific Drug Delivery
- Oily Drug Carriers in Cancer Chemotherapy. II. Preparation of Viscous Ethyl Oleate for Intraarterial Infusion Therapy and Its Disposition in Rats and Hamsters
- Fluorometric Determination of Amoxicillin
- Intestinal Absorption Mechanisms of Ampicillin Derivatives in Rats. I. Intestinal Absorption of Ampicillin Derivatives
- Fluorometric Determination of Ampicillin and Aminobenzylpenicilloic Acid in Presence of Pivampicillin in Body Fluids
- Fluorometric Determination of Ampicillin
- Effect of Azone on the Percutaneous Absorption of 5-Fluorouracil from Gels in Hairless Rats(Pharmaceutical)
- Effect of Ion Species and Their Concentration on the Iontophoretic Transport of Benzoic Acid through Poly(vinyl acetate) Membrane
- Effect of Several Penetration Enhancers on the Percutaneous Absorption of Indomethacin in Hairless Rats