Transformation and Excretion of Drugs in Biological Systems. X. Renal Excretion Mechanisms of Sulfonamides in Rabbits. (2)

概要

論文の詳細を見る
In order to clarify the renal excretion mechanisms of sulfonamides in rabbits the renal clearances of four sulfonamides, which were chosen of widely differing physico-chemical properties, were measured both in control and iodopyracet (IP) infusion periods. In control periods, all of the sulfonamides clearance were lower than inulin clearance, and descending order of these clearances were sulfamethizole (SMZ), sulfanilamide (SA), sulfisoxazole (SI) and sulfamethoxypyridazine (SMP). Sulfamethizole clearance corrected for the protein binding showed net secretion in the tubules, but the other sulfonamide clearances corrected showed net reabsorption. In iodopyracet infusion periods, the clearances of sulfamethizole and sulfisoxazole were significantly depressed below the inulin clearances, suggesting the secretion by the p-aminohippurate (PAH) mechanism and the reabsorption concurrently occurred. Further, the transfer rates in each direction into and out of the renal tubules were calculated with the four sulfonamides, and the determinating factors of the urinary excretions were discussed with reference to the physicochemical properties.
公益社団法人日本薬学会の論文
1974-03-25