Absorption and Excretion of Drugs. XXXIV. An Aspect of the Mechanism of Drug Absorption from the Intestinal Tract in Rats
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概要
- 論文の詳細を見る
Some qualitative discrepancies from the pH-partition theory demonstrated with barbituric acid derivatives previously were examined with various types of drugs and the confirmation of the suggestion that the binding process to the mucosal surface is an important factor of the absorption from the small intestine was made. The absorption of the ionized form of drugs was also interpreted by this binding factor. Furthermore, the dispositions of the small intestine were compared with that of the other parts of the gastrointestinal tract. The effect of the N-methyl configuration on the absorption was also found to persist the importance of the binding process.
- 公益社団法人日本薬学会の論文
- 1969-02-25
著者
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堀 了平
Faculty of Pharmaceutical Sciences, Hokkaido University
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西村 憲治
三共(株)第一生産技術研究所
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小西 良士
帝国製薬(株)製剤開発研
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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掛見 喜一郎
Faculty of Pharmaceutical Sciences, Kyoto University
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堀 了平
Department Of Pharmacy Kyoto University Hospital
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西村 祝子
Faculty of Pharmaceutical Sciences, Kyoto University
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西村 祝子
Faculty Of Pharmaceutical Sciences Kyoto University
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