Absorption of Drugs from the skeletal Muscle of the Rats. (4) Absorption of Cationic Drugs from the Muscle

概要

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Absorption profiles of intramuscularly administered drugs, protonated at the physiological pH, and the fundamental problems concerning the specificity of their absorption were studied, using the rat thigh muscle clearance method and in vitro uptake experiments. 1) The intramuscular absorption rates of cationic drugs were lower than that of neutral or anionic drugs. 2) The absorption of cationic drug from the skeletal muscle was diminished as its concentration increased, and the absorption of isonicotinamide was depressed by the presence of cationic drugs. These results indicated that the vascular effect of cationic drug might influence the cationic drug absorption. 3) It was noted that cationic drugs were incorporated more rapidly than the other drugs into the muscle pieces suggesting the storage or affinity of these drugs to the muscle tissue. This was proposed as one of the factors influencing the low-absorptive nature of cationic drugs.
社団法人日本薬学会の論文
1972-08-25