fasting and the Volume of Drug Distribution in the Rats
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概要
- 論文の詳細を見る
An attempt was made to elucidate the mechanisms of the drug absorption from intestine in the fasted rats. During fasting, weight of the body decreased gradually, whereas arterial hematocrit increased in proportion to the duration of food deprivation. It was observed that not only volume of blood plasma but also interstitial fluid volume decreased. These results could be interpreted as suggesting a decrease of distribution volume. In spite of the less absorption of drug from intestine, blood concentration of the fasted rats was higher than that of the controls. Volume of distribution was lost approximately 40% of the initial values during fasting for 60 hours. From these results, it was concluded that the diminished volume of distribution induced by fasting is one of the main causes which may bring about the decrease of drug absorption from intestine in the fasted rats. Other possible mechanisms were also discussed.
- 公益社団法人日本薬学会の論文
- 1975-04-25
著者
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瀬崎 仁
Faculty of Pharmaceutical Sciences, Kyoto University
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北澤 式文
Department of Pharmacy, Kyoto University Hospital
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瀬崎 仁
Faculty Of Pharmaceutical Sciences Kyoto University
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小室 徹雄
Department Of Pharmacy Kyoto University Hospital
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