Transmucosal Fluid Movement and Its Effect on Drug Absorption

概要

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The effect of transmucosal fluid movement on drug absorption from rat small intestine was studied, using in situ recirculation of perfusion method. Transmucosal fluid movement was obtained by using perfusion solutions of various tonicities of sodium chloride or glucose, and drugs emploved were sulfanilamide, sulfisoxazole and metoclopramide. The results obtained revealed that the drug absorption was increased with increasing the transmucosal fluid movement from lumen to blood, and in the case when the fluid was secreted, that is, counter directional fluid movement was obtained, the absorption was found to be decreased. These relations became apparent from figures in which the absorption on the horizontal axis and the ratio of the fluid movement on the vertical axis. Using the method of the illustration of figure, the effect of glucose on drug absorption had become occasionally apparent.
公益社団法人日本薬学会の論文
1975-08-25