Effect of Various Alcohols on the Intramuscular Absorption of Isonicotinamide in the Rat
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概要
- 論文の詳細を見る
The effect of various alcohols on the intramuscular absorption of water-soluble drug was studies using isonicotinamide as a model compound. It was found that linearity of the disappearance curves of the drug was maintained in the presence of the tested alcohols. The absorption inhibitory effect was also demonstrated when other alcohols of different classes were used, and it was increased with the increase of the molecular weight of the monohydric alcohols. Good correlations were demonstrated not only between the absorption inhibitory effect and denaturating power but also between the absorption inhibitory effect and the hemolytic effect of alcohols.
- 公益社団法人日本薬学会の論文
- 1977-11-25
著者
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北村 浩一
Faculty Of Pharmaceutical Sciences Kyoto University
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村西 昌三
Faculty of Pharmaceutical Sciences, Kyoto University
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瀬崎 仁
Faculty of Pharmaceutical Sciences, Kyoto University
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瀬崎 仁
Faculty Of Pharmaceutical Sciences Kyoto University
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三好 裕二
Faculty Of Pharmaceutical Sciences Kyoto University
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村西 昌三
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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小林 宏志
Faculty of Pharmaceutical Sciences, Kyoto University
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村西 昌三
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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小林 宏志
Faculty Of Pharmaceutical Sciences Kyoto University
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