Effect of Bile Salts on the Gastrointestinal Absorption of Drugs. IV. Site of Intestinal Absorption of Sodium Taurocholate and Its Consequence on Drug Absorption in the Rat
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概要
- 論文の詳細を見る
The site specificity in the absorption of sodium taurocholate (STC), one of the most common bile salts, and its consequence on drug absorption was investigated in the rat using the in situ perfusion technique. The absorption of STC by the jejunum was negligible both below and above the critical micellar concentration and it was absorbed solely by the ileum. Marked but variable change in absorbability of drugs was observed depending upon the physicochemical nature and the absorptive characteristics of drugs. The extent of the bile salt enhancement of the absorption of sulfaguanidine was more predominant in the ileum than in the jejunum, while the inhibitory effect of STC on the absorption of imipramine was less remarkable in the ileum. Possible mechanisms of these site specificity was discussed.
- 公益社団法人日本薬学会の論文
- 1972-08-25
著者
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瀬崎 仁
Faculty of Pharmaceutical Sciences, Kyoto University
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木村 聰城郎
Faculty of Pharmaceutical Sciences, Kyoto University
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瀬崎 仁
Faculty Of Pharmaceutical Sciences Kyoto University
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木村 聡城郎
大鵬薬品工業
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掛見 喜一郎
Faculty of Pharmaceutical Sciences, Kyoto University
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木村 聰城郎
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Okayama University
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木村 聰城郎
Faculty Of Pharmaceutical Sciences Okayama University
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