Effect of Ethanol on the Intramuscular Absorption of Water-soluble Drugs in the Rat
スポンサーリンク
概要
- 論文の詳細を見る
The effect of ethanol on the intramuscular absorption of water-soluble drugs from the rat thigh muscle was investigated. The presence of ethanol caused a pronounced decrease in the absorption rate of drugs, and the reduction was reflected by the decrease in plasma concentrations. It was also found that the absorption rate of drugs from the site of injection depends mainly on the concentration rather than the absolute amount of ethanol. A direct relationship between the relative viscosity of the injectable solution and the inhibitory absorption was demonstrated at lower concentrations of ethanol, but not at higher concentration. This shows that the inhibitory absorption effect of ethanol cannot be adequately explained by simple physicochemical factors, such as viscosity, but the existence of other factors must be acting. A constant intravenous infusion of ethanol showed no effect on the intramuscular absorption of drug. Furthermore, ethanol did not significantly change the permeability of the isolated mesentery to drug molecules. On the other hand, the connective tissue permeability was significantly decreased by the presence of ethanol and had a good correlation to the inhibitory effect of ethanol on the intramuscular absorption of drugs. From these observations, it can be concluded that the mechanism of the inhibitory effect of ethanol is mainly due to its influence on the extracellular spaces and the connective tissues permeability.
- 公益社団法人日本薬学会の論文
- 1977-11-25
著者
-
北村 浩一
Faculty Of Pharmaceutical Sciences Kyoto University
-
村西 昌三
Faculty of Pharmaceutical Sciences, Kyoto University
-
瀬崎 仁
Faculty of Pharmaceutical Sciences, Kyoto University
-
瀬崎 仁
Faculty Of Pharmaceutical Sciences Kyoto University
-
三好 裕二
Faculty Of Pharmaceutical Sciences Kyoto University
-
村西 昌三
Department of Biopharmaceutics, Kyoto Pharmaceutical University
-
小林 宏志
Faculty of Pharmaceutical Sciences, Kyoto University
-
吉崎 八重子
Faculty of Pharmaceutical Sciences, Kyoto University
-
村西 昌三
Department Of Biopharmaceutics Kyoto Pharmaceutical University
-
小林 宏志
Faculty Of Pharmaceutical Sciences Kyoto University
-
吉崎 八重子
Faculty Of Pharmaceutical Sciences Kyoto University
関連論文
- Lymphatic Transport of Griseofulvin in the Rat and the Possible Factors Determining the Extent of Lymphatic Absorption
- The Significance of Vehicle Oil Metabolism in the Absorption Process of Lipid-Soluble Compounds
- Regional Capacities of Gastrointestinal Absorption and Lymphatic Transport for Lipid-Soluble Dyes in Rats
- Studies on Pharmaceutical Modification of Anticancer Agents. I. Enhancement of Lymphatic Transport of Mitomycin C by Parenteral Emulsions
- Mechanism of the Intestinal Absorption of Drugs from Oil-in-Water Emulsions. VII. Role of Bile in the Lymphatic Transport of Lipid-Soluble Compounds from Triolein Emulsions
- Mechanism of the Intestinal Absorption of Drugs from Oil-in-Water Emulsions. VI. Absorption of Lipid-Soluble Dyes from Tributyrin and Triolein Emulsions in Rat Small Intestine
- Effect of Short-Chain Fatty Acids on the Intestinal Absorption of Drugs in the Rat
- Studies on the Stability of Drugs in Biological Media. III. Effect of Cupric Ion on the Stability and Antibacterial Activity of Penicillins in Culture Medium
- The Use of Liposomes as Enzyme Carriers. I. Dependence of Enzyme Stability on the Method of Preparation
- Potential Absorption of Heparin from the Small Intestine and the Large Intestine in the Presence of Monoolein Mixed Micelles
- AN ASSESSMENT OF GASTROINTESTINAL MUCOSAL DAMAGE IN VIVO : ENHANCEMENT OF URINARY RECOVERY AFTER ORAL ADMINISTRATION OF PHENOLSULFONPHTHALEIN IN ULCER RATS
- Dosage Form Characteristics of Microsphere-in-Oil Emulsion. II : Examination of Some Factors Affecting Lymphotropicity
- Effects of Various Absorption Promoters on Pulmonary Absorption of Drugs with Different Molecular Weights
- Assessment of Pharmaceutical Excipient-Induced Gastrointestinal Mucosal Damage in Rats in Vivo by Measuring the Permeation of Phenolsulfonphthalein
- Application of Liposomes to the Pharmaceutical Modification of the Distribution Characteristics of Drugs in the Rat
- Application of Drug-Containing Liposomes to the Duration of the Intramuscular Absorption of Water-Soluble Drugs in Rats
- Effect of Some Ionic and Nonionic Surfactants on the Intramuscular Absorption of Isonicotinamide
- Intramuscular Absorption of Drugs from Oily Solutions in the Rat
- Absorption of Drugs from the Skeletal Muscle of the Rats. V. Effect of Potassium Ion on the Absorption of Some Anionic Drugs
- Absorption of Drugs from the skeletal Muscle of the Rats. (4) Absorption of Cationic Drugs from the Muscle
- Absorption of Drugs from the Skeletal Muscle of the Rats. (3). Effect of Watersoluble Adjuvants and Vehicles on the Intramuscular Absorption
- Absorption of Drugs from the Skeletal Muscle of the Rats. (2)
- Absorption and Excretion of Drugs. XXXIX. The Absorption of Isonicotinic Acid Derivatives from the Skeletal Muscle of the Rats
- Studies on the Pharmaceutical Potentiation of Drugs. N. Biopharmaceutical Study on the Derivatives of p-Aminosalicylic Acid.
- Interaction of Parabens and Other Pharmaceutical Adjuvants with Plastic Containers
- Percutaneous Absorption of Butylparaben from Liposomes in Vitro
- Preservative Activity and in Vivo Percutaneous Penetration of Butylparaben Entrapped in Liposomes
- Studies on Pharmaceutical Modification of Anticancer Agents. II. Enhanced Delivery of Bleomycin into Lymph by Emulsions and Drying Emulsions
- Intestinal Absorption Aspect of Non-lipophilic Low Molecular Weight Drugs : A Case of Cephalexin and Cefazolin
- Role of Membrane Components, Glycocalyx and Lipid in Absorption of Water-soluble Dyes from the Rat Small Intestine
- Mechanisms of the Absorption of Water-soluble Dyes from the Rat Small Intestine
- Plasma Disposition and in Vivo and in Vitro Antitumor Activities of Mitomycin C-Dextran Conjugate in Relation to the Mode of Action
- Segmental Difference in Transmucosal Fluid Movement and Glucose Effect on Drug Absorption from Rat Gastrointestinal Tract
- Transmucosal Fluid Movement and Its Effect on Drug Absorption
- Role of Intestinal Mucus in the Absorption of Quinine and Water-soluble Dyes from the Rat Small Intestine
- Further Studies on the Mechanism of the Absorption of Ion Pair Complex from the Rat Small Intestine
- The Transport of a Drug to the Cerebrospinal Fluid Directly from the Nasal Cavity : The Relation to the Lipophilicity of the Drug
- Drug-induced Histological Changes and Its Consequences on the Permeability of the Small Intestinal Mucosa. II
- Drug-induced Histological Changes and Its Consequences on the Permeability of the Small Intestinal Mucosa. I. EDTA, Tetracycline, and Sodiun Laurylsulfate
- Regeneration Characteristics of Mitomycin C-Dextran Conjugate in Relation to Its Activity
- Biopharmaceutical Study of the Hepatobiliary Transport of Drugs. VI. Inhibition of Active Biliary Excretion of Organic Cations by Retrograde Infusion
- General Base Catalyzed Hydrolysis of Furylmethylketone Isonicotinoylhydrazone
- Studies on the Stability of Drugs in Biological Media. (2). Relationship between the Stability in Culture Media and Anti-bacterial Activity of Some Isoniazid Derivatives
- Studies on the Stability of Drugs in Biological Media. (1). Stability of Furylmethylketone Isonicotinoylhydrazone in Culture Media
- Effect of Various Alcohols on the Intramuscular Absorption of Isonicotinamide in the Rat
- Effect of Ethanol on the Intramuscular Absorption of Water-soluble Drugs in the Rat
- Effect of Complex Formation on the Intestinal Absorption of Tryptophan
- Studies on Molecular Interaction of Organic Molecules in Solution. I. Effects of Solvent on Molecular Interaction of Salicylic Acid with Caffeine
- Effect of Conformation of Molecules on Molecular Interaction. II. Nicotinamides and Pyridine Esters
- Inhibitory Mechanism of Imipramine on Barbiturate Metabolism in Rat Liver
- Effect of Bile Salts on the Gastrointestinal Absorption of Drugs. II. Mechanism of the Enhancement of the Intestinal Absorption of Sulfaguanidine by Bile Salts
- Enhancement of Membrane Permeability to a Poorly Absorbed Drug by Medium-Chain GLycerides : Effect of Medium-Chain Glycerides on the Release of Phenol Red from Egg Phosphatidylcholine Liposomes
- Intestinal Absorption of Drugs from Solubilized Systems of Long-Chain Fatty Acids in the Rat
- Blood Dispositions of Mitomycin C and a Lipophilic Prodrug after Intramuscular and Intravenous Administration in Liposomes and O/W Emulsion
- Effect of Mucosal Lipid Components on the Membrane Permeation of Water-Soluble Drugs
- Development of Lipophilic Prodrugs of Mitomycin C. III. Physicochemical and Biological Properties of Newly Synthesized Alkoxycarbonyl Derivatives
- Physico-chemical and Antitumor Characteristics of High Molecular Weight Prodrugs of Mitomycin C
- More Clarifications concerned with the Photodynamic Action of Riboflavine on the Intestinal Absorption of Drugs in the Rat
- Further Investigations of the Effect of Riboflavine Photolysates on the Intestinal Absorption of Certain Drugs in Rats and Their Mechanism of Action
- Effect of Bile Salts on the Gastrointestinal Absorption of Drugs. IV. Site of Intestinal Absorption of Sodium Taurocholate and Its Consequence on Drug Absorption in the Rat
- Mechanism of the Inhibitory Effect of Surfactants on Intramuscular Absorption of Drugs. (3)
- Mechanism of the Inhibitory Effect of Polysorbate 80 on Intramuscular Absorption of Drugs. (2)
- Mechanism of the Inhibitory Effect of Polysorbate 80 on Intramuscular Absorption of Drugs. (1)
- Effect of Some Cationic Drugs on the Intestinal Absorption of Pralidoxime Iodide
- Characterization of a Lipophilic Prodrug of 5-Fluorouracil with a Cholesterol Promoiety and Its Application to Liposomes
- Mechanism of Drug Absorption from Micellar Solution. II. Effect of Polysorbate 80 on the Absorption of Micelle-free Drugs
- Mechanism of Transfer of Bleomycin into Lymphatics by Bifunctional Delivery System via Lumen of Small Intestine
- Mechanism of the Intestinal Absorption of Drugs from Oil in Water Emulsions. V. Enhanced Absorption of Methyl Orange Adsorbed at Oil/Water Interface in Emulsions
- Mechanism of the Intestinal Absorption of Drugs from Oil in Water Emulsions. IV. Absorption from Emulsions containing the Higher Concentration of Emulsifier
- Mechanism of the Intestinal Absorption of Drugs from Oil in Water Emulsions. III. Absorption and Biotransformation of Methyl Orange
- Mechanism of Intestinal Absorption of Drugs from Oil in Water Emulsions. II. Absorption from Oily Solutions
- Mechanism of Intestinal Absorption of Drugs from Oil in Water Emulsions. I
- Analysis of Skin Penetration Enhancement Based on a Two-Layer Skin Diffusion Model with Polar and Nonpolar Routes in the Stratum Cornuem : Dose-Dependent Effect of 1-Geranylazacycloheptan-2-one on Drugs with Different Lipophilicities
- Hydrolytic and Associative Behavior of Aromatic Amides in Aqueous Solution
- Biopharmaceutical Study of the Hepato-biliary Transport of Drugs. VII. Improvement of the Bioavailability of Rifampicin by Dosage Form Design
- Biochemical and Biopharmaceutical Properties of Macromolecular Conjugates of Uricase with Dextran and Polyethylene Glycol
- Fate of Lipid and Encapsulated Drug after Intramuscular Administration of Liposomes Prepared by the Freeze-Thawing Method in Rats
- Effect of 1-Alkyl- or 1-Alkenylazacycloalkanone Derivatives on Penetration of Mitomycin C through Rat Skin(Pharmaceutical,Chemical)
- Absorption Characteristics of Macromolecular Prodrugs of Mitomycin C Following Intramuscular Administration
- Timed-Release of Mitomycin C from Its Agarose Bead Conjugate
- Biopharmaceutical Study of the Hepato-biliary Transport of Drugs. II. Roles of the Liver Cytoplasmic Y and Z Binding Proteins and T Binder on the Hepato-biliary Transport of Organic Anionic Compounds
- Prolonged Release of Bleomycin from Parenteral Gelatin Sphere-in-Oil-in-Water Multiple Emulsion
- Dosage Form Characteristics of Microsphere-in-oil Emulsions. I : Stability and Drug Release
- Absorption and Excretion of Drugs. XXIX. Effect of Surface-active Agents on Rectal Absorption of Sulfisoxazole from Oily Base
- Biopharmaceutical Study of the Hepato-biliary Transport of Drugs. VIII. Investigation of Hepatic Uptake of Organic Cations by Portal Infusion
- Enzyme Activities of Liver Plasma Membrane in Rat Bile after the Intrabiliary Retrograde Infusion of Triton X-100
- Biopharmaceutical Study of the Hepato-biliary Transport of Drugs. V. Hepatic Uptake and Biliary Excretion of Organic Cations
- Antitumor Activity of Timed-release Derivative of Mitomycin C, Agarose Bead Conjugate
- Mechanism of Drug Absorption from Micellar Solution. I. Absorption of Solubilized Vitamin A from the Rat Intestine
- Evaluation of Water in Oil and Microsphere in Oil Emulsions as a Specific Delivery System of 5-Fluorouracil into Lymphatics
- Biopharmaceutical Study of the Hepato-biliary Transport of Drugs. IV. Development of the Method to Investigate the Process of the Active Secretion of Drugs from the Hepatocytes into the Bile Canaliculi and Its Application to the Biliary Excretion of Organ
- Absorption and Excretion of Drugs. XXII. Absorption of Isoniazid and its Derivatives
- Biopharmaceutical Study of the Hepato-biliary Transport of Drugs. I. Hepato-biliary Transport of Non-metabolizing Organic Anionic Compounds in Rat
- Biopharmaceutical Study of the Hepato-biliary Transport of Drugs. III. Binding Characteristics of Bromphenol Blue and Amaranth to the Liver Cytoplasmic Y and Z Binding Proteins in Vitro
- fasting and the Volume of Drug Distribution in the Rats
- Effect of Fasting and Antineoplastic Agents on the Intestinal Absorption of Drugs in the Rats
- Absorption and Excretion of Drugs. XXVII. Effect of Nonionic Surface-Active Agents on Rectal Absorption of Sulfonamides
- Absorption and Excretion of Drugs. XXVI. Effect of Water-Soluble Bases on Rectal Absorption of Sulfonamides
- Absorption and Excretion of Drugs. XXV. On the Mechanism of Rectal Absorption of Sulfonamides
- Absorption and Excretion of Drugs. XL. Enhancement of the Rectal Absorption of Pharmaceutical Amines with Lauryl Sulfate and Saccharinate Anions