Drug-induced Histological Changes and Its Consequences on the Permeability of the Small Intestinal Mucosa. II
スポンサーリンク
概要
- 論文の詳細を見る
The influence of chelating agents such as EDTA disodium salt and tetracycline hydrochloride, and surfactants such as sodium lauryl sulfate, sodium desoxycholate, sodium taurocholate, benzethonium chloride, polysorbate 80,HCO-50,and Pluronic F 68,upon the intestinal mucosa was investigated by measuring the apparent exsorption rate constant (K) of sulfaguanidine administered intravenously in the rat. Except Pluronic F 68,all the agents showed increase in K with concomitant histological change. Because of this histological change the permeability of sulfaguanidine from the blood vessel to the intestinal lumen was found to increase. Further, the value of K and its change with time are suggested to be usable as an indicator of the damaging effect of drugs on the intestinal mucosa.
- 公益社団法人日本薬学会の論文
- 1975-03-25
著者
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灘井 種一
摂南大・薬
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瀬崎 仁
摂南大・薬
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灘井 種一
摂南大薬
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瀬崎 仁
Faculty Of Pharmaceutical Sciences Kyoto University
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立松 晃
名城大学薬学部
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立松 晃
Faculty of Pharmaceutical Science, Meijo University
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久米 求
名城大学薬学部
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