Absorption and Excretion of Drugs. XXXVI. Effect of Ca^<2+> on the Absorption of Tetracycline from the Small Intestine. (1)
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概要
- 論文の詳細を見る
Effect of Ca^<2+> on the absorption of tetracycline was examined in situ, in vitro, and in vivo. It was found that tetracycline disappeared faster from recirculation solution (a) in the presence of small amounts of Ca^<2+> at pH 6.2 and (b) in the presence of Ca^<2+> irrespective of its concentration at pH 8.0. At pH 8.0,partition ratio (isoamyl alcohol/water) of tetracycline increased in the presence of Ca^<2+>, exhibiting a similar pattern as that in recirculation experiments. Excretion data of tetracycline in man, however, showed that the antibiotic was less favorably absorbed in the presence of Ca^<2+>. These results suggested that tetracycline chelated with metal ions would be bound to intestinal wall and that absorption would be inhibited in the presence of Ca^<2+>.
- 公益社団法人日本薬学会の論文
- 1968-11-25
著者
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緒方 宏泰
Department Of Biopharmaceutics Meiji College Of Pharmacy
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緒方 宏泰
Faculty Of Pharmaceutical Sciences Kyoto University
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灘井 種一
摂南大・薬
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瀬崎 仁
摂南大・薬
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灘井 種一
摂南大薬
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灘井 種一
Faculty of Pharmaceutical Sciences, Setsunan University
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灘井 種一
Faculty Of Pharmaceutical Science Josai University
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