イヌおよびヒトの尿中にみられるBefunolol代謝物の主としてマススペクトロメトリーによる同定

概要

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Urinary metabolites of dogs and humans receiving befunolol (BF) were isolated by column chromatography on Amberlite XAD-2 resin and thin layer chromatography on silica gel. Unchanged BF and the following ten metabolites containing five glucuronides were identified in the dog by mass spectrometry (including GC/MS) : I, II, III, IV, V, O-glucuronide of 7-side-chain of BF (BF-7-OG), O-glucuronide of 7-side-chain of I (I-7-OG), O-glucuronide of 2-side-chain of I (I-2-OG), O-glucuronide of phenolic OH of III (III-4-OG) and O-glucuronide of phenolic OH of IV (IV-4-OG). The following five substances were detected in humans : BF, I, BF-7-OG, I-7-OG and I-2-OG. Neither III-4-OG, a major metabolite in the dog, nor its aglycone (III) was detected in humans, suggesting a species difference in the metabolic pathway of BF.
公益社団法人日本薬学会の論文
1979-09-25