Effect of Pharmaceutical Adjuvants on the Rectal Permeability of Drugs. III. Effect of Repeated Administration and Recovery of the Permeability

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Aqueous solutions of sodium deoxycholate, sodium lauryl sulfate, disodium ethylenediaminetetraacetate, and polyethylene glycol 400 were repeatedly perfused in the rectal lumen of rats. Changes in the permeability and the recovery of the altered histology of the rectal membrane were examined. An experimental apparatus which allowed perfusion of the adjuvant solutions in the rectal lumen without surgical operation was used. It was found that the epithelial cells affected by the adjuvants returned to the normal state within 2h after the pretreatment. However, the goblet cells did not show complete recovery even at 24h after the pretreatment, and the permeability of the membrane was still higher than the control value at that time. The permeability of the membrane on repeated treatment with the adjuvants was not increased as much as on the first treatment.
社団法人日本薬学会の論文
1983-11-25