Effect of Antacids on the Dissolution Behavior of Tetracycline and Methacycline
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概要
- 論文の詳細を見る
The effect of antacids on the dissolution behavior of tetracycline hydrochloride and methacycline hydrochloride from commercial capsules was studied. The dissolution of the tetracyclines was found to be markedly retarded by antacids such as aluminium silicate and magnesium trisilicate. An attempt was made to elucidate the mechanism of this effect. The results suggest that the effects of antacids on the dissolution may be due to the adsorption of the drugs on antacid particles as well as to the increased pH of the medium. A study was also carried out to determine the influence of stomachics using Cinnamomi Cortex as a test material. In dissolution experiments on commercial capsules, a significant dissolution inhibition by the stomachic was found.
- 公益社団法人日本薬学会の論文
- 1979-10-25
著者
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井上 ひとみ
Faculty Of Pharmaceutical Science Josai University
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宮崎 正三
東日本学園大学薬学部
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灘井 種一
Faculty of Pharmaceutical Sciences, Setsunan University
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宮崎 正三
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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灘井 種一
Faculty Of Pharmaceutical Sciences Setsunan University
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灘井 種一
Faculty Of Pharmaceutical Science Josai University
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宮崎 正三
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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