Comparative Study of the Interaction between Sulfamethizole and Ibufenac, Sulindac or Mepirizole at the Renal Level in Rats(Pharmaceutical,Chemical)
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概要
- 論文の詳細を見る
The effects of three non-steroidal anti-inflammatory drugs, ibufenac, sulindac and mepirizole, on the renal excretion of sulfamethizole in rats were investigated, in order to clarify the mechanisms involved. The clearance ratio of sulfamethizole was markedly decreased after infusion of ibufenac, while sulindac or mepirizole had no effect on the clearance ratio of sulfamethizole. From this result, it is speculated that the decrease of renal excretion of sulfamethizole caused by ibufenac is mainly due to competitive interaction between sulfamethizole and ibufenac at the renal secretary level. The correlation between the chemical structures of some anionic non-steroidal anti-inflammatory drugs and the characteristics of renal tubular transport is discussed.
- 社団法人日本薬学会の論文
- 1987-11-25
著者
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美濃 興三
国立療養所札幌南病院薬剤科
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高田 昌彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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宮崎 正三
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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千葉 一基
北海道医療大学薬学部
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千葉 一基
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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菊地 敏
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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美濃 興三
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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西村 成勲
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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高田 昌彦
北海道医療大 薬
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菊地 敏
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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西村 成勲
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon Gakuen University
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宮崎 正三
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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