Fundamental Pharmacokinetic Behavior of Sulfadimethoxine, Sulfamethoxazole and Their Biotransformed Products in Dogs
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概要
- 論文の詳細を見る
Plasma concentration profiles of sulfadimethoxine, sulfamethoxazole and their biotransformed products (N^4-acetate and N^1-glucuronide) in dogs were determined and their pharmacokinetic parameters were calculated by using a two-compartment open model. The apparent partition coefficients between chloroform and phosphate buffer were also determined. Decline in plasma levels of sulfadimethoxine and sulfamethoxazole was considerably accelerated by N^4-acetylation and N^1-glucuronidation. The elimination of sulfadimethoxine-N^1-glucuronide from plasma was more rapid than that of sulfadimethoxine-N^4-acetate, and a similar tendency was observed for sulfamethoxazole and its biotransformed products. N^4-Acetylation or N^1-glucuronidation of sulfadimethoxine and sulfamethoxazole decreased the lipid solubilities markedly in comparison with those of original sulfonamides.
- 公益社団法人日本薬学会の論文
- 1981-12-25
著者
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関川 彬
北海道医療大学薬学部製剤学教室
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高田 昌彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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関川 彬
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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八木 直美
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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関川 彬
北海道医療大学 薬学部免疫微生物学教室
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関川 彬
Faculty Of Pharmaceutical Sciences Hokkaido University
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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縣 功
Faculty of Pharmacy, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto.
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八木 直美
北海道医療大学 薬学部免疫微生物学教室
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伊藤 めぐみ
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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坂本 美恵子
Faculty of Pharmaceutical Sciences, Higashi Nippon Gakuen University
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川村 多恵子
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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田中 揚子
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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縣 功
Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University
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縣 功
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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坂本 美恵子
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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川村 多恵子
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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田中 揚子
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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