Protein Binding of Sulfonamides and Displacing Effects of Sulfinpyrazone on the Bound Sulfonamides in Nephrotic Patients in the Remissive Stage
スポンサーリンク
概要
- 論文の詳細を見る
The binding of sulfamethoxazole and sulfaphenazole to the serum protein of 10 nephrotic patients in the remissive stage, receiving prednisolone medication and alimento-therapy, was studied by equilibrium dialysis, and the results were compared with those for 10 normal subjects. The binding percentages of the two sulfonamides were found to be slightly impaired in the patients'serum as compared with normal serum. The binding characteristics of the patients'serum albumin were examined by calculating the percentage displacement of bound sulfonamides by sulfinpyrazone. The percentage displacement was considerably greater in the patients'serum than in normal serum. However, a proportional relationship between the percentage displacement and serum albumin concentration could not be found. The reason for the increased percentage displacement in the patients'serum remains unclear.
- 社団法人日本薬学会の論文
- 1980-04-25
著者
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高田 昌彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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八木 真美
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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門脇 純一
National Sanatorium of Nishi-Sapporo Hospital
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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山端 一宝
National Sanatorium Of Nishi-sapporo Hospital
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八木 直美
北海道医療大学 薬学部免疫微生物学教室
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大西 雅
National Sanatorium of Nishi-Sapporo Hospital
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川村 多恵子
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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川村 多恵子
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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