Thermally Gelling Poloxamine Synperonic T908 Solution as a Vehicle for Rectal Drug Delivery
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概要
- 論文の詳細を見る
Thermally reversible gels of the block copolymer, Synperonic T908,have been evaluated as vehicles for the rectal administration of indomethacin. Prolonged plasma levels of indomethacin following rectal administration in such gels was observed with the 40% w/w Synperonic T908 gels when compared with commercial suppositories. The release rate decreased with an increase in gel concentration over the range 30% to 40% w/w. Histological observation showed no damage to the rectal mucosal membrane in animals at 6h after the administration of a 40% w/w gel.
- 社団法人日本薬学会の論文
- 1995-08-15
著者
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高田 昌彦
北海道医療大学薬学部薬剤学講座
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小田 雅子
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaid
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高田 昌彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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宮崎 正三
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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小田 雅子
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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ATTWOOD David
Department of Pharmacy, University of Manchester
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小田 雅子
北海道医療大学薬学部薬剤学講座
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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高田 昌彦
北海道医療大 薬
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Attwood David
Department Of Pharmacy University Of Manchester
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Oda Masako
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaid
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon Gakuen University
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宮崎 正三
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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