Transformation and Excretion of Drugs in Biological Systems. V. Correlation between Renal Excretion and Biotransformation of Sulfadimethoxine
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概要
- 論文の詳細を見る
Sulfadimethoxine and its three biotransformed products in man were applied to renal clearance experiments in dogs to elucidate their renal excretion mechanisms. Clearance ratio of sulfadimethoxine is extremely low compared with each biotransformed product. Of three biotransformed products, clearance ratio of sulfadimethoxine-N^1-glucuronide greatly exceeded over the clearance ratio of the other two biotransformed products. Considerable proximal tubular secretion of sulfadimethoxine-N^4-acetate was observed. On the contrary, the proximal tubular secretion of sulfadimethoxine-N^1-glucuronide and sulfadimethoxine were insufficient. Sulfadimethoxine-N^1-glucuronide considerably reduced the affinity to dog plasma protein compared with sulfadimethoxine and sulfadimethoxine-N^4-acetate.
- 社団法人日本薬学会の論文
- 1971-05-25
著者
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高田 昌彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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堀 了平
Faculty of Pharmaceutical Sciences, Hokkaido University
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三沢 絢子
Pharmacy, Hokkaido University Hospital
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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三沢 絢子
Pharmacy Hokkaido University Hospital
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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堀 了平
Department Of Pharmacy Kyoto University Hospital
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