Chitosan and Sodium Alginate Based Bioadhesive Tablets for Intraoral Drug Delivery
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概要
- 論文の詳細を見る
Bioadhesive tablets for intraoral drug delivery were prepared by directly compressing the drug with a mixture of chitosan and sodium alginate in weight ratios of 4 : 1,1 : 1 and 1 : 4,and the adhesion and release characteristics of the prepared systems were evaluated in vitro and in vivo. Ketoprofen was used as a model drug. The magnitudes of the adhesion force of chitosan/alginate tablets were observed to be comparable to that of Aftach^<TM>, which is a typical commercial preparation of an oral mucosal adhesive tablet. Increasing the chitosan content in the tablets resulted in a decrease in the release rate of ketoprofen. When the tablets were administered to the sublingual site of rabbits, ketoprofen from the tablets with chitosan/alginate was rapidly absorbed without an initial sharp peak. Furthermore, the plasma concentration curves for the tablet with a 1 : 4 chitosan/alginate ratio showed a sustained release 3 h after administration. The data presented suggest that tablets prepared from chitosan and alginate are potential candidates for intraoral drug delivery.
- 社団法人日本薬学会の論文
- 1994-05-15
著者
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中山 章
北海道医療大学薬学部
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高田 昌彦
北海道医療大学薬学部薬剤学講座
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小田 雅子
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaid
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高田 昌彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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宮崎 正三
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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小田 雅子
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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ATTWOOD David
Department of Pharmacy, University of Manchester
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中山 章
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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ATTWOOD David
School of Pharmacy, University of Manchester
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小田 雅子
北海道医療大学薬学部薬剤学講座
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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高田 昌彦
北海道医療大 薬
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Attwood David
Department Of Pharmacy University Of Manchester
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Attwood David
School Of Pharmacy And Pharmaceutical Sciences University Of Manchester
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Oda Masako
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaid
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高田 昌彦
Faculty Of Pharmaceutical Sciences Higashi-nippon Gakuen University
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宮崎 正三
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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