Physical Properties of Pyrimidine and Purine Antimetabolites. II. Permeation of 5-Fluorouracil and 1-(2-Tetrahydrofuryl)-5-fluorouracil through Cellophane, Collagen, and Silicone Membranes
スポンサーリンク
概要
- 論文の詳細を見る
5-Fluorouracil and its derivative, 1-(2-tetrahydrofuryl)-5-fluorouracil (THFFU) were studied as to their permeability through cellophane, collagen, and silicone membranes. 5-Fluorouracil permeated through cellophane and collagen membranes slightly faster than THFFU. 5-Fluorouracil, however, permeated through the silicone membrane much more slowly than THFFU. Although the solubility of THFFU in silicone oil was much smaller than that in water, propylene glycol, or macrogol 400,its permeation rates through the silicone membrane from suspensions in these media were similar. The permeation rate of 5-fluorouracil through the silicone membrane from suspension in water was slightly greater than that in macrogol 400 in spite of smaller solubility in water. The permeation rate of THFFU from aqueous solutions through the silicone membrane was accelerated by the presence of sodium chloride and sodium sulfate whereas it was decelerated by sodium iodide. Permeation studies of THFFU through the silicone membrane at various pH values revealed that only the unionized form of the drug permeated through the membrane. The effect of temperature on permeability and flux of THFFU through the silicone membrane was also studied.
- 公益社団法人日本薬学会の論文
- 1976-11-25
著者
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井上 博之
Faculty Of Pharmaceutical Sciences Kyoto University
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中野 眞汎
Faculty of Pharmaceutical Sciences, Hokkaido University
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有田 隆一
Faculty of Pharmatical Science, Mukogawa Women's University
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital
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荒川 佳子
Department of Anesthesiology, Faculty of Medicine, Hokkaido University
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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有田 隆一
Faculty Of Pharmaceutical Sciences Mukogawa Womenus University
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荒川 佳子
Department Of Anesthesiology Faculty Of Medicine Hokkaido University
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荒川 佳子
Faculty of Pharmaceutical Sciences, Hokkaido University
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井上 博之
Faculty of Pharmaceutical Sciences, Kyoto University
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