Dissolution Mechanisms of Drug-Polyvinylpyrrolidone Coprecipitates in Aqueous Solution
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概要
- 論文の詳細を見る
Coprecipitates of sulfamethizole-polyvinylpyrrolidone (PVP) and sulfisoxazole-PVP were prepared at various ratios. The dissolution rates of the drugs in the coprecipitates were greater when the ratio of drug to PVP was smaller. The dissolution rate of sulfamethizole in the coprecipitate was greater when PVP of smaller molecular weight was used. Dissolution patterns were different for sulfamethizole-PVP coprecipitate and sulfisoxazole-PVP coprecipitate ; recrystallization of the drug was observed following the dissolution of sulfisoxazole-PVP coprecipitate, whereas no recrystallization was found in the dissolution of sulfamethizole-PVP coprecipitate. A new dissolution model for coprecipitate is proposed.
- 公益社団法人日本薬学会の論文
- 1979-05-25
著者
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中野 眞汎
Faculty of Pharmaceutical Sciences, Hokkaido University
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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関川 彬
Faculty Of Pharmaceutical Sciences Hokkaido University
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital
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有田 隆一
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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