Adsorption of Imipramine onto Activated Charcoal and a Cation Exchange Resin in Macrogol-Electrolyte Solution
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概要
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Adsorption of imipramine onto activated charcoal and a cation exchange resin, sodium polystyrene sulfonate were evaluated in macrogol (polyethylene glycol) electrolyte solution (PEG-ELS) and JP XII second medium. The maximum adsorptive capacity of activated charcoal for imipramine was 610 mg and 372 mg per g of charcoal in PEG-ELS and JP XII second medium, respectively. On the other hand, the maximum adsorptive capacity of sodium polystyrene sulfonate for the drug was 272 mg and 667 mg per g of the resin in PEG-ELS and JP XII second medium, respectively.Adsorption of imipramine onto both adsorbents was greater when macrogol was omitted from PEG-ELS than in PEG-ELS itself. Adsorption of the drug onto activated charcoal was decreased when sodium sulfonate or sodium bicarbonate was omitted from PEG-ELS, whereas that onto sodium polystyrene sulfonate was decreased only when sodium bicarbonate was omitted from PEG-ELS.
- 1992-11-25
著者
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中野 眞汎
Department Of Pharmacy Kumamoto University Hospital
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有森 和彦
Department of Pharmacy, Kumamoto University Hospital
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古川 恵美子
Department Of Pharmacy Kumamoto University
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中野 眞汎
Department of Clinical Pharmaceutics, Graduate School of Pharmaceutical Sciences, University of Shizuoka
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